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Oh, Turn It Off

Researchers uncover anti-CRISPR proteins that could help genetic engineering to be safer.

Derived from Listeria phages, the study found four new proteins that inhibit Cas9 activity, two of which also work in E. coli and engineered human cells.

Researchers at UCSF used CRISPR interference to knockdown lncRNA transcripts, then assayed for cell growth to get the final list of almost 500.

Aviv Regev and Jonathan Weissman have jumped into the single-cell RNA-sequencing, pooled CRISPR screen fray.

The funds will support TGen's efforts to use graphics processing units to reduce single-cell transcriptome data analysis times from months to days.

The projects focus on early treatment of prostate cancer and cataloguing mutations in difficult-to-diagnose diseases, among other things. 

When it comes to fully enrolling infants in sequencing studies, parental enthusiasm sometimes seems to wane due to logistical considerations and privacy concerns. 

Results from a study using the database showed that patients with high expression of a certain gene signature had better outcomes with radiation therapy than without it.

Researchers have developed a new pipeline to uncover novel transmission patterns in mother-infant microbiomes and marine metagenomes.

The healthcare provider organizations are tasked with managing patient enrollment in the Precision Medicine Initiative.

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A new paper says an effort to introduce gene drives into mosquitos altered the genetic makeup of the local mosquitos, but the company behind the project says the paper is flawed.

Virginia's Department of Forensic Science is offering attorneys a course on DNA testing, the Virginian-Pilot reports.

Researchers examine changes in the genomes of emmer wheat populations where the climate has warmed, the BBC reports.

In Cell this week: microinjection of CRISPR-Cas9 enables targeted mutations in Anolis, melanoma proteomic profiling, and more.