UCSF CRISPRoff Reversible Epigenome Editing Method Could Enable Safer, More Precise Therapeutics Premium UCSF and MIT researchers have developed a way to edit the epigenome and then completely reverse the changes, when needed. Prostate Cancer Study Shows Oncotype DX GPS Test Accurately Measures Long-Term Outcomes Premium The 20-year study showed the test provided an accurate assessment of the risk of long-term metastases and mortality for patients with localized prostate cancer. NephroSant Readies Launch of Kidney Transplant Rejection Assay Premium Following the launch of its urine-based Qsant assay later this year, the firm plans to develop updated versions of it with new biomarkers for different disease indications. Germline Genetic Variants May Influence Tumor Immune Microenvironment, Treatment Response A new study lends credence to the idea that pre-existing anti-cancer immunity depends heavily on patients' genetic background, according to one of the researchers. Lung Cancer Metastasis Study Relies on CRISPR-Based Method to Track Single-Cell Lineages Researchers traced the development of thousands of engineered human lung cancer cells within a mouse model of disease to examine metastasis. Jan 15, 2021 Mammoth Biosciences Taking Lead Role in DARPA-Funded Development of Pathogen Detection Tech Premium Jan 14, 2021 DARPA Awards $36.7M to Six Organizations for Gene Editing-Based Dx, Biosurveillance Tech Dec 21, 2020 COVID Assays Using CRISPR, Smartphones Show Potential for At-Home Testing Premium Dec 4, 2020 Breast Cancer Trial Data Supports Neoadjuvant Use of Natera Liquid Biopsy Premium Nov 9, 2020 Metagenomic Sequencing Can Quickly Identify Pathogens in Body Fluids, New Study Finds Oct 19, 2020 Light-Controlled CRISPR 'Off Switch' Enables Precise Editing, Fewer Off-Target Effects Premium Oct 16, 2020 SARS-CoV-2 Protein Interaction Study Reveals Key Proliferation Pathways, Possible Drug Targets Premium Oct 14, 2020 Epigenomic Study of Brain Development Uncovers Cell Type-Specific Regulatory Programs Oct 7, 2020 Post-mortem Melanocyte Mutations Provide Melanoma Clues Aug 20, 2020 Lung Cancer Therapy Leads to Transcriptional Changes, Single-Cell Study Shows Aug 18, 2020 Ebola Virus Appears to Undergo Distinct Changes in Bat, Human Host Cell Line Experiments Aug 14, 2020 Mission Bio Seeks to Increase Drug Trial Collaborations, Improve Gene and Cell Therapy Efficacy Premium Aug 10, 2020 Newborn Exome Sequencing Shows Potential to Help Find Inborn Errors of Metabolism Jul 29, 2020 Akoya Biosciences, UCSF Launch Predictive Cancer Biomarker Collaboration Jul 13, 2020 Metastatic Prostate Cancer Methylation Analysis Reveals Subtype, Ties to Driver Genes Jul 10, 2020 FDA Grants EUA for UCSF, Broad Institute, BioSewoom Coronavirus Tests Jun 23, 2020 Advanced CRISPR Screens Uncover Possible Novel Targets for Cancer Therapies Premium Jun 9, 2020 Genomic Analysis Indicates Multiple SARS-CoV-2 Introductions to Northern California Jun 2, 2020 10x Genomics, Collaborators Develop Targeted Single-Cell Gene Expression Methods Premium May 29, 2020 Tumor Microbiome Appears to Vary With Cancer Type Load More Breaking News Enzo Biochem, CLX Health Partner to Support COVID-19 Testing for International Travel Type 1 Diabetes GWAS, Fine-Mapping Leads to New Genetic Loci, Potential Drug Targets LSU Health Sciences Center Wins $2.4M to Lead SARS-CoV-2 Variant Sequencing Program NanoString Technologies, Parker Institute for Cancer Immunotherapy Partner on Cell Therapy Project BGI Americas Collaborating With Champions Oncology on Proteomic Cancer Research Personal Genome Diagnostics Inks Cancer Genomic Profiling Deal with Duke University Health System The Scan Missed Early Cases A retrospective analysis of blood samples suggests early SARS-CoV-2 infections may have been missed in the US, the New York Times reports. Limited Journal Editor Diversity A survey finds low diversity among scientific and medical journal editors, according to The Scientist. How Much of a Threat? Science writes that need for a provision aimed at shoring up genomic data security within a new US bill is being questioned. PNAS Papers on Historic Helicobacter Spread, Brain Development, C. difficile RNAs In PNAS this week: Helicobacter genetic diversity gives insight into human migrations, gene expression patterns of brain development, and more.