Single-cell sequencing yielded transcriptomic profiles for more than 20,000 cells, revealing gene expression changes that occur in response to treatment.
Ebola viruses passaged in bat renal cells appeared to be subject to RNA editing by host enzymes, while more adaptive mutations arose after passaging in a human kidney cell line.
Exome sequencing had lower sensitivity and specificity for finding inborn errors of metabolism than conventional screening, but appeared to refine mass spec-based results.
The group will use Akoya's Phenoptics platform to discover biomarkers for selecting neoadjuvant and adjuvant immunotherapies for early-stage breast cancer patients.
While a subset of metastatic castration-resistant tumors was marked by enhanced methylation, the analysis also pointed to recurrently hypomethylated regions.
