UCLA Microenvironments Give Clues to Distinct Immunotherapy Responses in Brain Metastases, Glioblastomas Investigators found microenvironment differences in checkpoint blockade immunotherapy-treated cases involving brain metastases versus recurrent glioblastoma. Treatment-Resistant Melanoma Genetic Signatures Emerge From Rapid Autopsy Analysis The study, which used organ samples from 11 rapid autopsies of patients who developed resistance to precision treatments, shows how cancer cells evolve under therapy. Bipolar Disorder Research Initiative Awards $15M for Brain Genetics, Omics Platforms BD2, a collaboration between three family philanthropies and the Milken Institute, made the awards to two teams for large-scale sequencing and a brain atlas. Survey Suggests Polygenic Embryo Screening Has Higher Public Acceptance Than Anticipated A national survey of more than 6,800 US participants asked about attitudes towards polygenic embryo screening, germline genome editing, and SAT prep courses. UCLA Team Uses Magnets, Microfluidics to Create Handheld Molecular Dx System Premium The device, which relies on magnets to move small amounts of fluid into different reaction chambers, can perform multiplexing and pooled testing. Nov 17, 2022 Non-Random Mating May Exaggerate Findings of Pleiotropy in Population Genetic Studies Nov 10, 2022 Cancer Patients in Early Trial Receive Personalized, CRISPR-Edited T-Cell Therapy Oct 12, 2022 Global Biobank Meta-Analysis Initiative Brings Greater Diversity to Global GWAS Sep 22, 2022 NIH Launches $500M Effort to Map Cells of the Human Brain Sep 19, 2022 Ethnic Identity, Genetics Provide Correlated but Distinct Clinical Information Premium Aug 19, 2022 High-Throughput Testing Reveals Genetic Programs, Pathogenic Variants in Neurodegenerative Disease Aug 16, 2022 Extracellular Vesicles Show Promise as Early-Stage Liver Cancer Diagnostic Premium Dec 8, 2021 Pacific Biosciences, UCLA Collaborate on Rare Disease Diagnostics Aug 19, 2021 Investigators See Future for NanoVelcro Cell Technology in Diagnosis of Pregnancy Complications Premium Jun 8, 2021 Deepcell, UCLA Partner to Study AI Cell Biology Platform Jun 8, 2021 NIH Earmarks $38M for Consortium Studying Polygenic Risk Scores in Diverse Populations May 7, 2021 Cystic Fibrosis-Related Airway Cell Changes Revealed in Single-Cell Transcriptome Study Mar 1, 2021 Host DNA Methylation Signatures May Predict Likelihood of Persistent, Resolving MRSA Infections Feb 11, 2021 UCLA Receives $29M Donation for Precision Genomic Medicine Feb 11, 2021 UCLA Researchers Look to Validate Saliva as Sample Type for Lung Cancer Molecular Diagnostics Premium Jan 27, 2021 Spectrum Solutions, UCLA Partner to Study Saliva-Based Early-Stage Lung Cancer Detection Nov 18, 2020 SummerBio Raises $7.3M, Implements SARS-CoV-2 Molecular Testing at Los Angeles Schools Nov 16, 2020 Somatic Mutations in Lung Cancer Patients With HLA Supertype B44 Influence Immunotherapy Response Nov 16, 2020 UCLA Health, Regeneron Collaborate on Whole-Exome Sequencing Oct 16, 2020 NIH Kicks Off Second Stage of 4D Nucleome Program With $142M in Research Grants Load More Breaking News SARS-CoV-2 Variants of Concerns Evolved to Modify Host Immune Response, Multiomics Study Shows People in the News at GA4GH, Mercy BioAnalytics, Deepcell, One Biosciences New Products Posted to GenomeWeb: Clinical Microbiomics, Integra Biosciences, DNAstack, Bruker Angolan Namib Desert Population Analysis Uncovers New Ancestry Group With Deep Divergence Cedars-Sinai Sets Up $25M Single Cell Precision Medicine Center The Scan Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. Small Study of Gene Editing to Treat Sickle Cell Disease In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema. Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.