UC Berkeley

The protease-activated Cas9 enzymes could reduce off-target effects and could be used to sense pathogens and trigger an immune response.

Stat News reports that the University of California and publisher Elsevier are fighting over open-access journal payments.

Prospective research suggests DNA and RNA sequencing can reveal pathogen, microbiome, and host expression features to detect lower respiratory tract infections.

In Genome Research this week: queen bee chromatin profiles, quantitative trait loci and allele-specific expression in wild house mice, and more.

The court upheld a judgement of no interference-in-fact from the Patent Trial and Appeal Board, leaving the Broad in control of key CRISPR IP.

This Week in Science

In Science this week: common metastatic driver genes, inhibitors of CRISPR, and more.

These Cas inhibitors — published in two studies — inhibit the activity of several Type V-A and Type I-C CRISPR systems, including several Cas12a orthologs.

The firm said it will use the funds to build its IP portfolio, expand its team, and develop an infrastructure for partners to build on its CRISPR platform.

This Week in PNAS

In PNAS this week: strategy for reactivating Rett syndrome-linked MECP2, small molecules able to suppress Staphylococcus aureus virulence, and more.

This Week in Nature

In Nature this week: novel soil-dwelling bacteria may be source of molecules with biomedical potential, and more.

Pages

Germany's Project DEAL has come to an agreement with the publisher Wiley over journal access and open-access publishing, ScienceInsider reports.

Researchers uncover additional loci associated with lifespan, which the Telegraph says could be folded into a genetic test.

A Canadian panel recommends public coverage of the gene therapy Kymriah if its cost comes down, the Globe and Mail reports.

In Nucleic Acids Research this week: new accurate quantification by sequencing approach, CNV breakpoints in Plasmodium falciparum, and more.