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Organization: TCGA

The Decade in Genomics: CRISPR, Single Cells, Long Reads, Clinical and Consumer Applications
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GenomeWeb asked a number of prominent researchers in the field via email about their top picks for notable developments or achievements in genomics during the 2010s.

Microbiome-Based Cancer Dx Emerges From Cancer Genome Atlas Reanalysis

Researchers re-examined whole-genome and whole-transcriptome sequencing TCGA studies from 33 cancer types and found unique microbial signatures.

Pan-Cancer Study Uncovers TP53 Mutation Consequences, Related Prognostic Expression Signature

An international team documented TP53 mutation-related genomic changes across dozens of cancer types using data generated with five platforms for the Cancer Genome Atlas project.

Mount Sinai Team Demonstrates Abilities of Proteogenomic Analysis Software
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In a recent study, the researchers used the software to analyze multi-omic ovarian cancer data generated by the TCGA and CPTAC initiatives.

Gastric Cancer Analysis in Young Populations Identifies Four Subtypes

The subtypes — which were distinguished from one another using proteomic data — were associated with proliferation, immune response, metabolism, and invasion.

Jan 14, 2019

Tumor Hypoxia Associated With Cancer Driver Mutation Signatures in 19 Tumor Types

Jan 10, 2019

Potential Prognostic Signature Described in HPV-Positive Squamous Cell Carcinomas

Jan 3, 2019

Glioblastoma Pathway Signatures, Treatment Responses Differ Between Male, Female Patients

Oct 25, 2018

Cancer Chromatin Maps Reveal Regulatory Features, Subtype Differences

Apr 6, 2018

Pan-Cancer Analysis Identifies Mutational Hotspots at the Protein Level
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Apr 5, 2018

TCGA's Pan-Cancer Atlas Papers Examine Clustering of Tumors, Key Alterations

Apr 3, 2018

TCGA Pan-Cancer Studies Describe New Tumor Features, Subtypes

Dec 4, 2017

Baylor Researchers Develop Tool for Analyzing TCGA, CPTAC Datasets
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Oct 19, 2017

Evolutionary Analysis Reveals Number, Nature of Mutations Under Positive Selection in Cancer

Jun 15, 2017

Data Analytics Startup Medley Genomics Targets Genomic Heterogeneity; Initial Focus on Cancer
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Jan 23, 2017

Cervical Cancer Analysis Yields Novel Changes, Therapeutic Targets

Jan 4, 2017

Esophageal Cancer Genomic Analysis Uncovers Disease Subtypes

Jul 12, 2016

Red Hair-Linked Gene Variants Also Associated With Increased Skin Cancer Mutations

Jun 30, 2016

Annai Preps NGS Data Management Platform for Formal Launch; Unveils Early Customer
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Jan 28, 2016

Integrated Glioma Analysis Uncovers Epigenetics-based Subtypes

Dec 22, 2015

WUSTL Team Finds Inherited Mutations Common Across Cancer Types

Nov 5, 2015

Molecular Analysis Places Primary Prostate Tumors Into Number of Subtypes

Nov 5, 2015

TCGA Analysis Points to Kidney Cancer Subtypes With Prognosis, Treatment Clues

Jun 18, 2015

TCGA Defines New Subtypes for Cutaneous Melanoma

Jun 11, 2015

NEJM Studies Define New Molecular Subtypes for Glioma
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Breaking News
The Scan

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.

Study Looks at Parent Uncertainties After Children's Severe Combined Immunodeficiency Diagnoses

A qualitative study in EJHG looks at personal, practical, scientific, and existential uncertainties in parents as their children go through SCID diagnoses, treatment, and post-treatment stages.

Antimicrobial Resistance Study Highlights Key Protein Domains

By screening diverse versions of an outer membrane porin protein in Vibrio cholerae, researchers in PLOS Genetics flagged protein domain regions influencing antimicrobial resistance.

Latent HIV Found in White Blood Cells of Individuals on Long-Term Treatments

Researchers in Nature Microbiology find HIV genetic material in monocyte white blood cells and in macrophages that differentiated from them in individuals on HIV-suppressive treatment.