Organization: TCGA The Decade in Genomics: CRISPR, Single Cells, Long Reads, Clinical and Consumer Applications Premium GenomeWeb asked a number of prominent researchers in the field via email about their top picks for notable developments or achievements in genomics during the 2010s. Microbiome-Based Cancer Dx Emerges From Cancer Genome Atlas Reanalysis Researchers re-examined whole-genome and whole-transcriptome sequencing TCGA studies from 33 cancer types and found unique microbial signatures. Pan-Cancer Study Uncovers TP53 Mutation Consequences, Related Prognostic Expression Signature An international team documented TP53 mutation-related genomic changes across dozens of cancer types using data generated with five platforms for the Cancer Genome Atlas project. Mount Sinai Team Demonstrates Abilities of Proteogenomic Analysis Software Premium In a recent study, the researchers used the software to analyze multi-omic ovarian cancer data generated by the TCGA and CPTAC initiatives. Gastric Cancer Analysis in Young Populations Identifies Four Subtypes The subtypes — which were distinguished from one another using proteomic data — were associated with proliferation, immune response, metabolism, and invasion. Jan 14, 2019 Tumor Hypoxia Associated With Cancer Driver Mutation Signatures in 19 Tumor Types Jan 10, 2019 Potential Prognostic Signature Described in HPV-Positive Squamous Cell Carcinomas Jan 3, 2019 Glioblastoma Pathway Signatures, Treatment Responses Differ Between Male, Female Patients Oct 25, 2018 Cancer Chromatin Maps Reveal Regulatory Features, Subtype Differences Apr 6, 2018 Pan-Cancer Analysis Identifies Mutational Hotspots at the Protein Level Premium Apr 5, 2018 TCGA's Pan-Cancer Atlas Papers Examine Clustering of Tumors, Key Alterations Apr 3, 2018 TCGA Pan-Cancer Studies Describe New Tumor Features, Subtypes Dec 4, 2017 Baylor Researchers Develop Tool for Analyzing TCGA, CPTAC Datasets Premium Oct 19, 2017 Evolutionary Analysis Reveals Number, Nature of Mutations Under Positive Selection in Cancer Jun 15, 2017 Data Analytics Startup Medley Genomics Targets Genomic Heterogeneity; Initial Focus on Cancer Premium Jan 23, 2017 Cervical Cancer Analysis Yields Novel Changes, Therapeutic Targets Jan 4, 2017 Esophageal Cancer Genomic Analysis Uncovers Disease Subtypes Jul 12, 2016 Red Hair-Linked Gene Variants Also Associated With Increased Skin Cancer Mutations Jun 30, 2016 Annai Preps NGS Data Management Platform for Formal Launch; Unveils Early Customer Premium Jan 28, 2016 Integrated Glioma Analysis Uncovers Epigenetics-based Subtypes Dec 22, 2015 WUSTL Team Finds Inherited Mutations Common Across Cancer Types Nov 5, 2015 Molecular Analysis Places Primary Prostate Tumors Into Number of Subtypes Nov 5, 2015 TCGA Analysis Points to Kidney Cancer Subtypes With Prognosis, Treatment Clues Jun 18, 2015 TCGA Defines New Subtypes for Cutaneous Melanoma Jun 11, 2015 NEJM Studies Define New Molecular Subtypes for Glioma Premium Load More Breaking News Alzheimer's Disease Phosphoproteomics Study Uncovers Signaling Abnormalities Genetic Analysis of H. Pylori Indicates Americas Colonized in One Main Migration Event BillionToOne Raises $55M in Series B Financing GeninCode to Launch Cardiovascular Disease Risk Tests in US With Eversana Top Five Articles on GenomeWeb Last Week: Illumina, Liquid Biopsy, Thermo Fisher Scientific, and More Becton Dickinson Sues Beckman Coulter Over Cell Analysis, Sorting IP The Scan Another Resignation According to the Wall Street Journal, a third advisory panel member has resigned following the US Food and Drug Administration's approval of an Alzheimer's disease drug. Novavax Finds Its Vaccine Effective Reuters reports Novavax's SARS-CoV-2 vaccine is more than 90 percent effective in preventing COVID-19. Can't Be Used The US Food and Drug Administration says millions of vaccine doses made at an embattled manufacturing facility cannot be used, the New York Times reports. PLOS Papers on Frozen Shoulder GWAS, Epstein-Barr Effects on Immune Cell Epigenetics, More In PLOS this week: genome-wide association study of frozen shoulder, epigenetic patterns of Epstein-Barr-infected B lymphocyte cells, and more.