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Swiss Institute of Bioinformatics

Chromosome 22 Copy Number Variants Linked to Traits in General Population

A phenome-wide association study and follow-up analyses found 17 continuous or binary traits that are associated with chromosome 22q11.2 CNVs.

Computational Biologists Seek Continuous Benchmarking of Bioinformatics Technology
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The in-development Renku method from the Swiss Data Science Center was built to update automatically as new metrics are introduced.

Human Glycome Project Forges Ahead With Support From New England Biolabs, Genos, Waters
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The new partnership will support the analysis of glycans in 30,000 human samples by the end of 2021.

Ancient Human Migrations Unraveled Through Population Genomics Studies

Genome sequences of individuals from populations around the world provided insights into out-of-Africa migrations and Aboriginal Australian ancestry.

New Swiss Initiative to Mine Genomics Data for Personalized Health Network
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The Swiss Personalized Health Network will create a new national infrastructure for sharing clinical data among university hospitals, institutes, and others involved in health research.

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Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.