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St. Jude

The funds will be used to expand the PharmGKB database and support the activities of the Clinical Pharmacogenetics Implementation Consortium.

The funding will support work identifying the mechanisms underlying the differential responses among pediatric and adult ALL patients to therapy.

Researchers found alterations that activate the RAS-MAPK pathway in 18 of 23 relapse neuroblastoma tumors tested.

A missense change in CDKN2A turned up through a genome-wide association study involving thousands of childhood acute lymphoblastic leukemia cases and controls.

By combining structural variants with read depth change data, the software is able to find CNAs in whole-genome sequence that other methods miss.

The group has developed tables that match genotype, phenotype, and clinical recommendations to help inform therapy choices at the point of care. 

Whole-exome sequencing shows that relapse in acute lymphoblastic leukemia is driven by cancer cells with sneakier, rather than more numerous, mutations.

Researchers at St. Jude and elsewhere identified a promoter SNP associated with peripheral neuropathy in vincristine-treated children with acute lymphoblastic leukemia.

By testing hundreds of children with brain tumors who were treated with cisplatin, researchers identified risk variants related to cisplatin ototoxicity.

NEWYORK (GenomeWeb) – Personalized medicine proponents have long argued that pharmacogenomics can increase drug efficacy and reduce dangerous adverse outcomes, especially if PGx information is collected and stored preemptively so that it can be available at the point of prescribing and useful in

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A new approach may help limit the number of fish that are mislabeled at markets or restaurants, according to New Scientist.

Nature News reports that researchers in Japan hope to soon test the use of reprogrammed stem cells to treat damaged corneas.

At Slate, the R Street Institute's Nila Bala discusses the privacy rights of suspects that genetic genealogy approaches in law enforcement bring up.

In PNAS this week: numerous mobile genetic elements contribute to Vibrio cholerae drug resistance, troponin I mutations in sudden infant deaths, and more.