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This Week in Cell

In Cell this week: DNA methylation and T cell exhaustion, longevity in C. elegans, and more.

Suspicious variants were uncovered through analyses of pediatric cancer survivors from the St. Jude Lifetime Cohort Study and Childhood Cancer Survivor Study.

Results from up to eight stages of mouse or human retina development highlight the importance of histone modifications and other epigenetic shifts during differentiation.

Roughly one-fifth of adult cases of acute lymphoblastic leukemia are marked by Philadelphia chromosome-like expression. 

Children's Genomics

US News and World Report takes a look at genomics' role at pediatric hospitals.

Expression profiles of 1,900 B-cell acute lymphoblastic leukemia cases point to the presence of a subtype marked by rearrangements in transcription factor DUX4.

The partners will exchange all information they have on genetic mutations leading to cancer with an eye toward accelerating research and drug discovery efforts.

Scientists introduced an indel to a promoter region to mimic a benign, naturally-occurring mutation that activated fetal hemoglobin production.

Researchers from St. Jude Children's and the German Cancer Research Center used methylation and gene expression analyses to uncover the subtypes.

The deal could bolster Genelex's business, but CEO Kristine Ashcraft is hopeful that the integration with Epic Systems a sign of growing acceptance of pharmacogenetic testing.

Pages

New US Department of Commerce rules will affect supercomputing in China, according to the Wall Street Journal.

A new analysis finds that it will be more than a century until female computer scientists publish at the same rate as their male counterparts, ScienceInsider reports.

Broad Institute researchers describe an approach they've dubbed "DNA microscopy."

In PLOS this week: epigenetic changes following hepatitis C virus treatment, metagenomic analysis of Ugandan children with febrile illness, and more.