St. Jude
Pharmacotyping Links Childhood Leukemia Subtypes to Treatment Response
With drug sensitivity and genomic profiles on acute lymphoblastic leukemia cells, coupled with patient data, researchers saw pharmacotypes related to treatment response and outcomes.
Gene Expression Score IDs Breast Cancer Patients Responsive to Histone Deacetylase 6 Inhibitor
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The gene activity signature could serve as a predictive biomarker for HDAC6 inhibitor response among metastatic breast cancer patients.
St. Jude, Broad Institute, Dana-Farber Partner to Advance Pediatric Cancer Research
The institutions have invested $60 million into the Pediatric Cancer Dependencies Accelerator to study cancer vulnerabilities and develop treatments.
Genetic Risk Score Helps Predict Severe Obesity Later in Life in Childhood Cancer Survivors
Risk prediction models picked up four times as many childhood cancer survivors prone to severe obesity in adulthood when genetic risk scores were included.
ALL Genomes Marked by High DNA Methylation Levels
Starting with samples from 82 pediatric cases of B-cell or T-cell acute lymphoblastic leukemia, researchers found widespread hypermethylation across ALL genomes.