St. Jude Pediatric Medulloblastoma Subgroups May Benefit from Lower-Dose Radiation Therapy The study found certain patients did not benefit from lower doses of radiation therapy, suggesting the need for molecular selection. Fetal Hemoglobin Gene Regulation Study Points to Potential Therapeutic Targets Regulatory elements revealed in the study could potentially be targeted by base editors to treat conditions like sickle cell disease. CRISPR-Cas9 Genome Editing Can Lead to Extensive Chromosome Rearrangements A study showed that chromothripsis, a mutational process that can lead to congenital disease and cancer, can result from on-target editing with Cas9. Genetic Loci Influence Risk of Cardiomyopathy in Pediatric Cancer Survivors of African Ancestry Researchers uncovered genetic loci that may influence why childhood cancer survivors of African ancestry are more likely to develop therapy-linked cardiomyopathy. Nature Presents Approach to Uncover Regulatory Noncoding Variants in Cancer, More In Nature this week: a method called cis-X combines whole-genome and transcriptome sequencing data to identify regulatory noncoding variants, and more. Jun 5, 2020 Secondary Tumor Risk in Pediatric Cancer Survivors Linked to Germline Variants, Treatment Type May 6, 2020 Pediatric Cancer Patients With Solid Tumors Have Many Druggable Germline Alterations Apr 2, 2020 Cancer Researchers Discover Novel Inherited Mutation Predisposing Children to Medulloblastoma Mar 9, 2020 Integrated Genomic Analysis Highlights Potential Strategy for Overcoming Some ALL Resistance Jan 23, 2020 Startup BioSkryb Eyes Oncology Applications for Single-Cell DNA Sequencing Premium Jan 8, 2020 BioSkryb Raises $11.5M in Seed Funding Dec 19, 2019 Blood-Based Sequencing Test Identifies Pediatric Cancer Infections Before Symptoms Dec 10, 2019 ASH Study Points to Distinct AML, MDS Subtypes Based on Genomic, Transcriptomic Analysis Oct 18, 2019 HudsonAlpha Wins $12.4M in NIH Grants for Population Genomics, Pediatric Sequencing Aug 7, 2019 Pediatric Cancer Researchers, Clinicians Look to Enhance Molecular Data Collection, Distribution Jul 25, 2019 Germline BRCA2 Mutations Linked to Pediatric Non-Hodgkin Lymphoma Risk Jul 24, 2019 Medulloblastoma Molecular Subtypes Refined With Single-Cell Transcriptome Data Jul 23, 2019 Pediatric Oncologists Employing Variety of Sequencing Strategies for Treatment, Research Premium Jun 25, 2019 Pediatric Cancer Big Data Initiatives Could Help Set Best Practices for Sequencing, Data Sharing Premium Jun 18, 2019 Next-Generation Sequencing of Pediatric Cancer Patients Could Transform Treatment Paradigms Premium May 16, 2019 NCI Pediatric MATCH Trial Interim Data Shows 24 Percent of Patients Eligible for Targeted Therapy Premium Apr 2, 2019 Common Variant May Increase Stroke Risk Among Cranial Radiation-Treated Childhood Cancer Survivors Mar 4, 2019 Spitzoid Melanoma Sequencing Reveals MEK Inhibitor Target Oct 26, 2018 Breast Cancer Risk Linked to Genetics, Treatment Exposures in Childhood Cancer Survivors Oct 12, 2018 Clinical PGx Implementation Consortium Developing API for Guidelines Integration Into Health Records Premium Load More Breaking News Beckman Coulter, Invitae Partner to Develop NGS Library Prep Applications Sick Infants Profiled with WGS See Better Diagnosis, More Care Changes UC Santa Cruz Center for Live Cell Genomics Wins $13.5M NIH Grant Genetron Health, Impact Therapeutics Partner for Anti-Cancer Drug, CDx Development Canaccord Genuity Initiates Coverage of Pacific Biosciences With Buy Rating Alternative Genetic Counseling Approach Leads to Higher Patient Satisfaction, Study Suggests The Scan Highly Similar Researchers have uncovered bat viruses that are highly similar to SARS-CoV-2, according to Nature News. Gain of Oversight According to the Wall Street Journal, the Biden Administration is considering greater oversight of gain-of-function research. Lasker for mRNA Vaccine Work The Scientist reports that researchers whose work enabled the development of mRNA-based vaccines are among this year's Lasker Award winners PLOS Papers on Causal Variant Mapping, Ancient Salmonella, ALK Fusion Test for NSCLC In PLOS this week: MsCAVIAR approach to map causal variants, analysis of ancient Salmonella, and more.