St. Jude
Pediatric Medulloblastoma Subgroups May Benefit from Lower-Dose Radiation Therapy
The study found certain patients did not benefit from lower doses of radiation therapy, suggesting the need for molecular selection.
Fetal Hemoglobin Gene Regulation Study Points to Potential Therapeutic Targets
Regulatory elements revealed in the study could potentially be targeted by base editors to treat conditions like sickle cell disease.
CRISPR-Cas9 Genome Editing Can Lead to Extensive Chromosome Rearrangements
A study showed that chromothripsis, a mutational process that can lead to congenital disease and cancer, can result from on-target editing with Cas9.
Genetic Loci Influence Risk of Cardiomyopathy in Pediatric Cancer Survivors of African Ancestry
Researchers uncovered genetic loci that may influence why childhood cancer survivors of African ancestry are more likely to develop therapy-linked cardiomyopathy.
Nature Presents Approach to Uncover Regulatory Noncoding Variants in Cancer, More
In Nature this week: a method called cis-X combines whole-genome and transcriptome sequencing data to identify regulatory noncoding variants, and more.