St. Jude Pharmacotyping Links Childhood Leukemia Subtypes to Treatment Response With drug sensitivity and genomic profiles on acute lymphoblastic leukemia cells, coupled with patient data, researchers saw pharmacotypes related to treatment response and outcomes. Gene Expression Score IDs Breast Cancer Patients Responsive to Histone Deacetylase 6 Inhibitor Premium The gene activity signature could serve as a predictive biomarker for HDAC6 inhibitor response among metastatic breast cancer patients. St. Jude, Broad Institute, Dana-Farber Partner to Advance Pediatric Cancer Research The institutions have invested $60 million into the Pediatric Cancer Dependencies Accelerator to study cancer vulnerabilities and develop treatments. Genetic Risk Score Helps Predict Severe Obesity Later in Life in Childhood Cancer Survivors Risk prediction models picked up four times as many childhood cancer survivors prone to severe obesity in adulthood when genetic risk scores were included. ALL Genomes Marked by High DNA Methylation Levels Starting with samples from 82 pediatric cases of B-cell or T-cell acute lymphoblastic leukemia, researchers found widespread hypermethylation across ALL genomes. Apr 29, 2022 St. Jude Program Installing Nanopore Sequencing in Low-Income Countries to Diagnose Pediatric Blood Cancers Premium Apr 20, 2022 Proof-of-Principle Study Points to Possibility of Monitoring Pediatric ALL With Plasma Samples Jun 11, 2021 Pediatric Medulloblastoma Subgroups May Benefit from Lower-Dose Radiation Therapy May 7, 2021 Fetal Hemoglobin Gene Regulation Study Points to Potential Therapeutic Targets Apr 13, 2021 CRISPR-Cas9 Genome Editing Can Lead to Extensive Chromosome Rearrangements Dec 8, 2020 Genetic Loci Influence Risk of Cardiomyopathy in Pediatric Cancer Survivors of African Ancestry Jun 22, 2020 BioSkryb, St. Jude Expand Licensing Deal for Dx Applications of Single-Cell Tech Jun 5, 2020 Secondary Tumor Risk in Pediatric Cancer Survivors Linked to Germline Variants, Treatment Type May 6, 2020 Pediatric Cancer Patients With Solid Tumors Have Many Druggable Germline Alterations Apr 2, 2020 Cancer Researchers Discover Novel Inherited Mutation Predisposing Children to Medulloblastoma Mar 9, 2020 Integrated Genomic Analysis Highlights Potential Strategy for Overcoming Some ALL Resistance Jan 23, 2020 Startup BioSkryb Eyes Oncology Applications for Single-Cell DNA Sequencing Premium Jan 8, 2020 BioSkryb Raises $11.5M in Seed Funding Dec 19, 2019 Blood-Based Sequencing Test Identifies Pediatric Cancer Infections Before Symptoms Dec 10, 2019 ASH Study Points to Distinct AML, MDS Subtypes Based on Genomic, Transcriptomic Analysis Oct 18, 2019 HudsonAlpha Wins $12.4M in NIH Grants for Population Genomics, Pediatric Sequencing Aug 7, 2019 Pediatric Cancer Researchers, Clinicians Look to Enhance Molecular Data Collection, Distribution Jul 25, 2019 Germline BRCA2 Mutations Linked to Pediatric Non-Hodgkin Lymphoma Risk Jul 24, 2019 Medulloblastoma Molecular Subtypes Refined With Single-Cell Transcriptome Data Jul 23, 2019 Pediatric Oncologists Employing Variety of Sequencing Strategies for Treatment, Research Premium Load More Breaking News Simple HealthKit Raises $8M in Series A Round Top Five Articles on GenomeWeb Last Week: Quantum-Si Layoffs, UBS Coverage Initiations, More LumiraDx Secures FDA Emergency Use Authorization, UK Approval for COVID-19, Flu Test Rarity Bioscience Raises Additional €500,000 Cancer Prognoses Informed by Module-Based Approach, Study Finds The Scan UK Team Presents Genetic, Epigenetic Sequencing Method Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers. DNA Biobank Developed for French Kidney Donors, Recipients The KiT-GENIE biobank described in the European Journal of Human Genetics contains DNA samples, genotyping profiles, immune patterns, and clinical features for thousands of kidney donors or transplant recipients in Nantes, France. Cardiometabolic Disease May Have Distinct Associations With Microbial Metabolites in Blood, Gut By analyzing gut microbes in combination with related metabolites in feces and blood, researchers in Nature Communications found distinct cardiometabolic disease relationships at each site. Study Reveals New Details About Genetics of Major Cause of Female Infertility Researchers in Nature Medicine conducted a whole-exome sequencing study of mote than a thousand patients with premature ovarian insufficiency.