St. Jude
Cancer Predisposition Variants Increase Secondary Cancer Mortality Risk in Pediatric Survivors
In data from childhood cancer survivors, researchers saw an uptick in secondary cancer-related mortality in those with cancer-linked germline variants.
Elevated Epigenetic Aging Puts Childhood Cancer Survivors at Risk of Obesity, Other Conditions
A cross-sectional study of epigenetic aging in 2,846 pediatric cancer survivors also found that the rate at which epigenetic aging changed differed between age groups.
Pharmacotyping Links Childhood Leukemia Subtypes to Treatment Response
With drug sensitivity and genomic profiles on acute lymphoblastic leukemia cells, coupled with patient data, researchers saw pharmacotypes related to treatment response and outcomes.
Gene Expression Score IDs Breast Cancer Patients Responsive to Histone Deacetylase 6 Inhibitor
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The gene activity signature could serve as a predictive biomarker for HDAC6 inhibitor response among metastatic breast cancer patients.
St. Jude, Broad Institute, Dana-Farber Partner to Advance Pediatric Cancer Research
The institutions have invested $60 million into the Pediatric Cancer Dependencies Accelerator to study cancer vulnerabilities and develop treatments.