Seattle Children's Hospital Newly Funded NIH Genome Characterization Centers Aim to Elucidate Human Somatic Mosaicism Premium The five centers, funded as part of NIH's Somatic Mosaicism across Human Tissues Network, will analyze over 2,200 samples to study somatic variants in humans. Pacific Biosciences, GeneDx, UW Collaborate on Google-Funded Study of WGS in Neonatal Care Google will contribute expertise on informatics methods and provide an undisclosed amount of funding, including for reagents, to the project. SeqFirst Results Highlight Diagnostic Gains From Rapid Genome Sequencing in Critically Ill Newborns Premium Data from the first phase of the project showed that the conventional genetic testing approach would have missed 42 percent of infants diagnosed in the study. New Epigenomic Biomarker Could Predict CAR T-Cell Therapy Resistance in Advanced Childhood Leukemia Premium At AACR, researchers described how pediatric ALL patients who don't respond to anti-CD19 CAR T-cell therapy have cancers with a unique, stem cell-like epigenome. Genomic Answers for Kids Project Advances Long-Read Sequencing for Rare Disease Testing Premium The GA4K program, run by Children's Mercy Research Institute, aims to build a testing framework for pediatric patients with undiagnosed rare disease. Apr 28, 2021 Illumina, GeneDx Partner With University of Washington on Whole-Genome Sequencing Study in Kids Nov 20, 2020 Increased Adoption of Whole-Genome Sequencing Testing Hinges on Acceptance by Payors, Providers Premium Breaking News GenomeWeb Top 40 Down 10 Percent in September, Outpacing Decline in Broader Market Natera Submits Signatera Bladder Cancer PMA Module to FDA FDA Grants Emergency Use Authorizations for POC COVID Tests from Tangen Biosciences, SD Biosensor Top Five Articles on GenomeWeb Last Week: FDA Proposal for LDT Oversight, Adela $48M Financing, More FDA Grants Marketing Authorization for Invitae Hereditary Cancer DNA Sequencing Test The Scan Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. Small Study of Gene Editing to Treat Sickle Cell Disease In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema. Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.