Sanger Institute

Data from hundreds of individuals suggest that the country's populations are genetically diverse, with a long history of genetic isolation and differentiation.

With sequence data for hundreds of advanced breast cancer samples, investigators identified genetic alterations shared with — and distinct from — those in primary tumors.

Investigators sequenced 3,700-year-old Canaanite genomes and compared them to present-day populations to explore the historical people's origin and fate.

Scientists from The Wellcome Trust Sanger Institute, Public Health England, and elsewhere sequenced the genomes of 209 MRSA isolates collected in Europe from 1960 to 1989.

The institute will house the Centre for Genomic Pathogen Surveillance to monitor antibiotic-resistant bacteria worldwide.

Examining more than half of its genome, researchers found the parasite's success is due to stripping its genome down to essential genes.

Effect of Sex

Researchers find a number of traits differ by sex and could affect mouse model studies, according to Reuters.

Even in schizophrenia cases lacking intellectual disability, investigators found that rare mutations in genes normally resistant to loss-of-function changes were enriched.

Researchers saw an over-representation of rarer variants in isolated groups when they sequenced thousands of individuals from 10 European populations.

Researchers led by the Wellcome Trust Sanger Institute also reported that combined chromothripsis and amplification might be a driving mechanism of osteosarcoma.

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While gene therapies may have high price tags, they could be cheaper than the cost of managing disease, according to MIT's Technology Review.

Researchers are looking for markers that indicate which cancer patients may respond to immunotherapies, the Associated Press writes.

In Nature this week: paternal age associated with de novo mutations in children, and more.

Nature News writes that researchers are still wrangling over the role of the p-value.