Salk Institute Center for Multiomic Human Brain Atlas to Tackle Methylation, Gene Expression for $500M NIH Project Premium The Salk Institute for Biological Studies is leading this effort as a key part of NIH's new BRAIN Initiative Cell Atlas Network. NIH Launches $500M Effort to Map Cells of the Human Brain The BRAIN Initiative Cell Atlas Network (BICAN) will rely heavily on single-cell sequencing and bioinformatics to create brain cell atlases and maps of cell interactions. ENCODE Phase Three Offers New Insights Into Genomic Regulatory Regions, Organization In more than a dozen new papers, ENCODE researchers reported on analyses of the human and mouse genomes, using new data types and additional tissues. CRISPR Researchers Develop First In Vivo Editing System Targeting Non-Coding DNA The team tested the system in living mice with progeria, inserting a normal copy of the LMNA gene into the animals to diminish features of the disease. Noncoding Structural Variants Highlighted in Integrated Cancer Genome Analysis Using Hi-C, genome sequencing, and optical mapping, researchers profiled structural variants in multiple cancer cell lines, leading to potential non-coding drivers. Apr 16, 2018 Bioinformatics Pipeline Annotates CRISPR Repeats, Cas Genes; Assembles Data in One Repository Premium Mar 23, 2018 CRISPR Startup Arbor Biotechnologies, Salk Institute Concurrently Discover New Cas13d Enzyme Premium Mar 22, 2018 Early Life Experiences Affect Retrotransposon Accumulation in Mouse Brains Jan 16, 2018 Salk Institute, Indivumed Enter Research Partnership Dec 7, 2017 Researchers Use CRISPR to Epigenetically Alter Disease Phenotypes in Mice Oct 24, 2017 NIH Announces BRAIN Initiative Grants for 2017 Aug 10, 2017 Neuronal Subtypes Revealed Using Single-Cell Methylation Sequencing Jul 28, 2017 Chromatin Structure Less Organized Than Textbooks Say, According to New Study Jan 24, 2017 NSF, USDA Award Microbiome Research Grants Dec 6, 2016 Functional Microprotein Characterized in Human Cells Sep 12, 2016 L1s Contribute to Genomic Diversity of Healthy Somatic Brain Cells Jul 18, 2016 Arabidopsis Studies Tap 1,001 Genomes Data to Explore Genomic, Epigenomic, Speciation History Sep 18, 2015 Researchers Find Age-Related Protein Changes Differ Across Organs in Rats Jun 1, 2015 Human Methylome Map Reveals Variations by Tissue, Non-Canonical Methylation Apr 23, 2015 Salk Scientists Develop Method to Edit Mutations in Germline Mitochondrial DNA Premium Nov 18, 2014 Study Sees Transcriptional Differences in Mouse, Human Tissues Jun 3, 2014 Salk Nets $25M Gift, Closes in on $300M Fundraising Goal May 22, 2014 Salk Lands $3M for Glenn Center for Aging Research Dec 3, 2013 Study Suggests RNA from Single Nuclei Sufficient for Sequencing Premium Sep 13, 2013 Scripps/Salk Rat Study Lays Out Comprehensive Profile of Long-lived Proteins Implicated in Aging Premium Load More Breaking News Mainz Biomed to Initiate Pivotal US Clinical Study for Colorectal Cancer Early Detection Test Pacific Biosciences, Boston Children's Hospital to Collaborate on Rare Disease Variant Pilot Project Caris Life Sciences, Hummingbird Bioscience Partner on Anti-HER3 Therapy Advancement Gut Microbiome Characteristics Tied to Depressive Symptoms in New Studies Bluestar Genomics to Study Pancreatic Cancer Early Detection Test in Type 2 Diabetes Patients The Scan Quality Improvement Study Compares Molecular Tumor Boards, Central Consensus Recommendations With 50 simulated cancer cases, researchers in JAMA Network Open compared molecular tumor board recommendations with central consensus plans at a dozen centers in Japan. Lupus Heterogeneity Highlighted With Single-Cell Transcriptomes Using single-cell RNA sequencing, researchers in Nature Communications tracked down immune and non-immune cell differences between discoid lupus erythematosus and systemic lupus erythematosus. Rare Disease Clues Gleaned From Mobile Element Insertions in Exome Sequences With an approach called MELT, researchers in the European Journal of Human Genetics uncovered mobile element insertions in exomes from 3,232 individuals with or without developmental or neurological abnormalities. Team Tracks Down Potential Blood Plasma Markers Linked to Heart Failure in Atrial Fibrillation Patients Researchers in BMC Genomics found 10 differentially expressed proteins or metabolites that marked atrial fibrillation with heart failure cases.