Salk Institute ENCODE Phase Three Offers New Insights Into Genomic Regulatory Regions, Organization In more than a dozen new papers, ENCODE researchers reported on analyses of the human and mouse genomes, using new data types and additional tissues. CRISPR Researchers Develop First In Vivo Editing System Targeting Non-Coding DNA The team tested the system in living mice with progeria, inserting a normal copy of the LMNA gene into the animals to diminish features of the disease. Noncoding Structural Variants Highlighted in Integrated Cancer Genome Analysis Using Hi-C, genome sequencing, and optical mapping, researchers profiled structural variants in multiple cancer cell lines, leading to potential non-coding drivers. Bioinformatics Pipeline Annotates CRISPR Repeats, Cas Genes; Assembles Data in One Repository Premium The researchers have made the pipeline, called CRISPRdisco, free for other scientists to use through Github, and are hoping the community will also help refine and update it. CRISPR Startup Arbor Biotechnologies, Salk Institute Concurrently Discover New Cas13d Enzyme Premium The startup was cofounded by the Broad Institute's Feng Zhang and Harvard's David Walt among others, and raised $15.6 million in June. Mar 22, 2018 Early Life Experiences Affect Retrotransposon Accumulation in Mouse Brains Jan 16, 2018 Salk Institute, Indivumed Enter Research Partnership Dec 7, 2017 Researchers Use CRISPR to Epigenetically Alter Disease Phenotypes in Mice Oct 24, 2017 NIH Announces BRAIN Initiative Grants for 2017 Aug 10, 2017 Neuronal Subtypes Revealed Using Single-Cell Methylation Sequencing Jul 28, 2017 Chromatin Structure Less Organized Than Textbooks Say, According to New Study Jan 24, 2017 NSF, USDA Award Microbiome Research Grants Dec 6, 2016 Functional Microprotein Characterized in Human Cells Sep 12, 2016 L1s Contribute to Genomic Diversity of Healthy Somatic Brain Cells Jul 18, 2016 Arabidopsis Studies Tap 1,001 Genomes Data to Explore Genomic, Epigenomic, Speciation History Sep 18, 2015 Researchers Find Age-Related Protein Changes Differ Across Organs in Rats Jun 1, 2015 Human Methylome Map Reveals Variations by Tissue, Non-Canonical Methylation Apr 23, 2015 Salk Scientists Develop Method to Edit Mutations in Germline Mitochondrial DNA Premium Nov 18, 2014 Study Sees Transcriptional Differences in Mouse, Human Tissues Jun 3, 2014 Salk Nets $25M Gift, Closes in on $300M Fundraising Goal May 22, 2014 Salk Lands $3M for Glenn Center for Aging Research Dec 3, 2013 Study Suggests RNA from Single Nuclei Sufficient for Sequencing Premium Sep 13, 2013 Scripps/Salk Rat Study Lays Out Comprehensive Profile of Long-lived Proteins Implicated in Aging Premium Mar 6, 2013 Team Tracks Epigenomic Diversity in Arabidopsis Jan 23, 2013 Salk Lands $42M Grant to Launch Genomic Medicine Center Load More Breaking News Alzheimer's Disease Phosphoproteomics Study Uncovers Signaling Abnormalities Genetic Analysis of H. Pylori Indicates Americas Colonized in One Main Migration Event BillionToOne Raises $55M in Series B Financing GeninCode to Launch Cardiovascular Disease Risk Tests in US With Eversana Top Five Articles on GenomeWeb Last Week: Illumina, Liquid Biopsy, Thermo Fisher Scientific, and More Becton Dickinson Sues Beckman Coulter Over Cell Analysis, Sorting IP The Scan Another Resignation According to the Wall Street Journal, a third advisory panel member has resigned following the US Food and Drug Administration's approval of an Alzheimer's disease drug. Novavax Finds Its Vaccine Effective Reuters reports Novavax's SARS-CoV-2 vaccine is more than 90 percent effective in preventing COVID-19. Can't Be Used The US Food and Drug Administration says millions of vaccine doses made at an embattled manufacturing facility cannot be used, the New York Times reports. PLOS Papers on Frozen Shoulder GWAS, Epstein-Barr Effects on Immune Cell Epigenetics, More In PLOS this week: genome-wide association study of frozen shoulder, epigenetic patterns of Epstein-Barr-infected B lymphocyte cells, and more.