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Salk Institute

Role of Super-Enhancers in Triggering Pancreatic Cancer Tumor Growth Explored in Study

Investigators at the Salk Institute for Biological Studies identified DNA regulatory regions that lead to human pancreatic cancer cell line growth.

New Imaging Method Enables Multiplexed Spatial Gene Expression Analysis in Plants
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Developed by Salk Institute researchers, PHYTOMap can profile expression of multiple genes within whole-mount plant tissue at a cellular level.

Center for Multiomic Human Brain Atlas to Tackle Methylation, Gene Expression for $500M NIH Project
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The Salk Institute for Biological Studies is leading this effort as a key part of NIH's new BRAIN Initiative Cell Atlas Network.

NIH Launches $500M Effort to Map Cells of the Human Brain

The BRAIN Initiative Cell Atlas Network (BICAN) will rely heavily on single-cell sequencing and bioinformatics to create brain cell atlases and maps of cell interactions.

ENCODE Phase Three Offers New Insights Into Genomic Regulatory Regions, Organization

In more than a dozen new papers, ENCODE researchers reported on analyses of the human and mouse genomes, using new data types and additional tissues.

Aug 28, 2019

CRISPR Researchers Develop First In Vivo Editing System Targeting Non-Coding DNA

Sep 10, 2018

Noncoding Structural Variants Highlighted in Integrated Cancer Genome Analysis

Apr 16, 2018

Bioinformatics Pipeline Annotates CRISPR Repeats, Cas Genes; Assembles Data in One Repository
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Mar 23, 2018

CRISPR Startup Arbor Biotechnologies, Salk Institute Concurrently Discover New Cas13d Enzyme
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Mar 22, 2018

Early Life Experiences Affect Retrotransposon Accumulation in Mouse Brains

Jan 16, 2018

Salk Institute, Indivumed Enter Research Partnership

Dec 7, 2017

Researchers Use CRISPR to Epigenetically Alter Disease Phenotypes in Mice

Oct 24, 2017

NIH Announces BRAIN Initiative Grants for 2017

Aug 10, 2017

Neuronal Subtypes Revealed Using Single-Cell Methylation Sequencing

Jul 28, 2017

Chromatin Structure Less Organized Than Textbooks Say, According to New Study

Jan 24, 2017

NSF, USDA Award Microbiome Research Grants

Dec 6, 2016

Functional Microprotein Characterized in Human Cells

Sep 12, 2016

L1s Contribute to Genomic Diversity of Healthy Somatic Brain Cells

Jul 18, 2016

Arabidopsis Studies Tap 1,001 Genomes Data to Explore Genomic, Epigenomic, Speciation History

Sep 18, 2015

Researchers Find Age-Related Protein Changes Differ Across Organs in Rats

Jun 1, 2015

Human Methylome Map Reveals Variations by Tissue, Non-Canonical Methylation

Apr 23, 2015

Salk Scientists Develop Method to Edit Mutations in Germline Mitochondrial DNA
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Nov 18, 2014

Study Sees Transcriptional Differences in Mouse, Human Tissues

Jun 3, 2014

Salk Nets $25M Gift, Closes in on $300M Fundraising Goal

May 22, 2014

Salk Lands $3M for Glenn Center for Aging Research

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The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.