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Researchers found ancestry-specific risk variants and developed a better polygenic risk score based on a GWAS and subsequent meta-analysis.
In Nature this week: genome-wide association study of 42 diseases among Japanese population, transfer RNA modifications, and more.
The GWAS of more than 200,000 Japanese individuals across 42 diseases identified 25 novel loci shared between Japanese and European populations.
Both studies emerged from the ongoing Human Cell Atlas project and could help scientists decide on the best approaches to use in various contexts.
The effort is focused on building an atlas of immune cell types found across a range of Asian population groups as part of the Human Cell Atlas project.
Retraction Watch reports that a fourth paper linked to the STAP stem cell scandal has now been retraction.
A large genome-wide association in breast cancer cases and controls from Japan led to common variants linked to disease risk at two new and nine known risk loci.
In PNAS this week: cytotoxic CD4 T cell signature in supercentenarians, evolutionary history of beetles, and more.
A single-cell transcriptome study found increased numbers of cytotoxic CD4 T cells, which could be an adaptation to the later stages of aging.
In Nature this week: GWAS of cigarette smoking behaviors, set of gene expression predictors for schizophrenia, and more.
Politico notes that the Biden Administration has not yet nominated a permanent Food and Drug Administration commissioner.
Anthony Fauci also informed the World Health Organization executive board that the US would be joining the COVAX initiative, according to CNBC.
A new preprint suggests some SARS-CoV-2 variants could affect the effectiveness of current vaccines, the Associated Press reports.
In Nature this week: Australian lungfish provides details on the movement of vertebrate life from water to land, and more.