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Riken

A large genome-wide association in breast cancer cases and controls from Japan led to common variants linked to disease risk at two new and nine known risk loci.

In PNAS this week: cytotoxic CD4 T cell signature in supercentenarians, evolutionary history of beetles, and more.

A single-cell transcriptome study found increased numbers of cytotoxic CD4 T cells, which could be an adaptation to the later stages of aging.

In Nature this week: GWAS of cigarette smoking behaviors, set of gene expression predictors for schizophrenia, and more.

A genome-wide association study of nearly 60 quantitative traits highlighted the links between genes, clinical measurements, and disease.

Adverse Eye Effect

Riken researchers conducting a trial of an iPS cell treatment of age-related macular degeneration say a patient experienced swelling, according to the Japan Times.

Such an atlas could enable investigators to understand how genetic variants impact disease risk, define drug toxicities, improve therapies, and advance regenerative medicine.

In Nature this week: genomic regions affecting parental care in mice, and more.

A pair of studies also uncovered atrial fibrillation risk loci specific to East Asian populations, particularly near SH3PXD2A.

The FANTOM consortium generated an atlas of nearly 30,000 human long non-coding RNAs that suggests more than 19,000 of them are functional.

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Forensic genetic firm Verogen has bought the genetic genealogy site GEDmatch.

Researchers have 3D-printed plastic bunnies that encase the information needed to make more such bunnies in DNA, according to Discover magazine.

Dan Rather, the former CBS Evening News anchor and executive producer of a new documentary, writes at the Guardian that everyone needs to know about CRISPR.

In PNAS this week: analysis of FOXA1 upregulation in ER-positive breast cancer, gene editing to correct recessive dystrophic epidermolysis bullosa, and more.