Princess Margaret Hospital

Expression and copy number profiles from histologically normal duct tissue near tumors suggest a "field of cancerization" may exist in epithelial cells around cancer.

Using genomic data from large cancer cell line collections, investigators identified versions of spliced genes that spell better or worse drug response.

The researchers are developing a province-wide registry of targeted sequencing test results for the study that will be made available to other cancer researchers.

With exome sequences, RNA sequences, and methylation profiles, investigators uncovered differences between radiation-induced and sporadic forms of meningioma.

The initiatives are being funded with C$24 million over two years and will focus on acute leukemia, immuno-oncology, and brain, ovarian, and pancreatic cancer.

Researchers demonstrated the feasibility of finding multiple myeloma mutations with a new circulating tumor DNA sequencing method known as LB-Seq. 

In two studies, researchers sequenced nearly 500 tumors to uncover hallmarks of aggressive prostate cancer.

A team led by University of Toronto researchers developed the signature as a clinical assay that could predict treatment response.

Based on the results, the researchers, based in Toronto, have initiated a clinical study in Ontario, called OCTANE, that involves a number of cancer centers in the province.

Results from a recent study clarify some conflicting prior determinations, and provide a new rationale to further explore the FCGR2A biomarker in prospective trials.

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The UK's Human Fertility and Embryology Authority calls for consumer genetic testing companies to warn customers that testing could uncover family secrets, according to the Guardian.

The New York Times reports that United Nations delegates have been discussing how to govern the genetic resources of the deep sea.

Researchers have transplanted edited cells into mice that appear to combat cocaine addiction, New Scientist reports.

In PNAS this week: analysis of proteolytic enzymes secreted by circulating tumor cells, phylogenetic study of Fv1 evolution, and more.