Princess Margaret Hospital

Expression and copy number profiles from histologically normal duct tissue near tumors suggest a "field of cancerization" may exist in epithelial cells around cancer.

Using genomic data from large cancer cell line collections, investigators identified versions of spliced genes that spell better or worse drug response.

The researchers are developing a province-wide registry of targeted sequencing test results for the study that will be made available to other cancer researchers.

With exome sequences, RNA sequences, and methylation profiles, investigators uncovered differences between radiation-induced and sporadic forms of meningioma.

The initiatives are being funded with C$24 million over two years and will focus on acute leukemia, immuno-oncology, and brain, ovarian, and pancreatic cancer.

Researchers demonstrated the feasibility of finding multiple myeloma mutations with a new circulating tumor DNA sequencing method known as LB-Seq. 

In two studies, researchers sequenced nearly 500 tumors to uncover hallmarks of aggressive prostate cancer.

A team led by University of Toronto researchers developed the signature as a clinical assay that could predict treatment response.

Based on the results, the researchers, based in Toronto, have initiated a clinical study in Ontario, called OCTANE, that involves a number of cancer centers in the province.

Results from a recent study clarify some conflicting prior determinations, and provide a new rationale to further explore the FCGR2A biomarker in prospective trials.


Robert Redfield is floated as the next director of the US Centers for Disease Control and Prevention, the Washington Post reports.

The New York Times writes that the National Institutes of Health's All of Us Research Program is "ambitious" and that some are concerned it might be overly so.

Representative Lamar Smith's criticism of the National Science Foundation has "changed the nature of the conversation," according to ScienceInsider.

In PLOS this week: non-coding RNA function in yeast, transcriptomic profiles of malaria parasites, and more.