Several researchers have been collaborating with single-cell handling firm Cellenion to develop new tools that could expand access to single-cell proteomics.
The aim is to improve the accuracy of the protein measurements commonly reported as the output of proteomic experiments and uncover obscured biological signals.
The advances improve the separating power and the ion efficiency of the lab's SLIM technology, enabling more sensitive and higher resolution mass spec work.
Researchers at the laboratory have developed a single-cell proteomics workflow capable of reproducibly quantifying 1,000-plus proteins per cell.
Highlights included mass spec-focused developments like data-independent acquisition and ion mobility along with platforms including Thermo Fisher's Q Exactive.