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Peter MacCallum Cancer Centre

End-Stage Ovarian Cancer Marked by Rampant Treatment Resistance, Multiple Clones

By profiling multiple tumors per patient, researchers found pronounced polyclonal disease and diverse resistance mechanisms in end-stage high-grade serous ovarian carcinoma.

SEngine Organoid Testing Leads to Treatment Change for Two Metastatic Colorectal Cancer Patients

The researchers said their new study supports the clinical utility of their test, which combines genomic and drug screening analyses of organoids to guide cancer treatment.

Genomic Analyses of Metastatic Lesions in Lethal Breast Cancer Reveal Heterogeneity, Evolution

Researchers analyzed the exomes of metastatic tumor samples from patients who died of breast cancer to piece together the genomic evolution.

Q&A: Peter Mac's Ian Campbell on Cancer Genomics, Next-Gen Technologies, and Research in Australia
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Name: Ian Campbell Title: Associate professor, Peter MacCallum Cancer Centre

Copy Number Analyses ID Gene Tied to Treatment Resistance in Ovarian Cancer

NEW YORK (GenomeWeb News) – An array-based analysis by researchers from Australia and elsewhere has identified a gene that is often missing in ovarian cancers that become resistant to liposomal doxorubicin chemotherapy, hinting that it may serve as a marker for such acquired resistance.
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Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.