Osaka University
Global Biobank Meta-Analysis Initiative Brings Greater Diversity to Global GWAS
The initiative combines biobank data from around the globe to provide deeper and more representative insights into the genetics of human health.
Dilated Cardiomyopathy Gene Mutations Point to Possible Therapeutic Strategy
Homozygous loss-of-function mutations in the BAG5 gene turned up in a subset of inherited DCM patients, and BAG5 appeared amenable to gene therapy in mouse models.
Multi-Ancestry GWAS Leads to Loci Linked to Hundreds of Human Phenotypes
Using genotyping data for hundreds of thousands of individuals from Japan and beyond, researchers found more than 5,000 new associations, as well as disease classification clues.
Genetic Risk for High Blood Pressure, Obesity Also Linked to Shorter Lifespan
An analysis of biobank data from Japan, the UK, and Finland found the link between obesity and lifespan was stronger among individuals with European ancestry.
Analysis of Major Histocompatibility Complex Region Highlights Diversity
Japanese researchers developed a catalog of HLA alleles that they used to perform a phenome-wide association study of the MHC and about a hundred phenotypes.