OICR

Researchers found that air pollution levels affected the expression of genes linked to cardio-metabolic and respiratory traits more than genetic ancestry.

Expression and copy number profiles from histologically normal duct tissue near tumors suggest a "field of cancerization" may exist in epithelial cells around cancer.

In Nucleic Acids Research this week: disease network resource, database of epigenetic consequences of de novo mutations, and more.

Using genomic data from large cancer cell line collections, investigators identified versions of spliced genes that spell better or worse drug response.

Called GA4GH Connect, it calls on the alliance's 500-plus members to develop new data sharing standards for use in major international genomic data initiatives.

The software, developed by researchers at the Ontario Institute for Cancer Research, uses machine learning methods to classify mutations as germline or somatic.

The initiatives are being funded with C$24 million over two years and will focus on acute leukemia, immuno-oncology, and brain, ovarian, and pancreatic cancer.

Two research groups reported on statistical methods for uncovering methylated cytosine and/or adenine bases using electrical current cues from Oxford Nanopore sequencers.

In two studies, researchers sequenced nearly 500 tumors to uncover hallmarks of aggressive prostate cancer.

An analysis of copy number changes and genomic rearrangements in more than 100 tumors suggests chromothripsis may contribute to pancreatic cancer evolution.

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Oxford Nanopore Technologies is looking into dual listings in London and Hong Kong, according to the South China Morning Post.

The New York Times looks into medical research funding in the US and how the grant system might not be funding the best work.

US lawmakers proposed increasing the National Science Foundation budget, including its facilities account, Science reports.

In PNAS this week: effects of gene deletions on bacterial metabolic networks, genetic responses to sea star wasting disease, and more.