Researchers found that air pollution levels affected the expression of genes linked to cardio-metabolic and respiratory traits more than genetic ancestry.

Expression and copy number profiles from histologically normal duct tissue near tumors suggest a "field of cancerization" may exist in epithelial cells around cancer.

In Nucleic Acids Research this week: disease network resource, database of epigenetic consequences of de novo mutations, and more.

Using genomic data from large cancer cell line collections, investigators identified versions of spliced genes that spell better or worse drug response.

Called GA4GH Connect, it calls on the alliance's 500-plus members to develop new data sharing standards for use in major international genomic data initiatives.

The software, developed by researchers at the Ontario Institute for Cancer Research, uses machine learning methods to classify mutations as germline or somatic.

The initiatives are being funded with C$24 million over two years and will focus on acute leukemia, immuno-oncology, and brain, ovarian, and pancreatic cancer.

Two research groups reported on statistical methods for uncovering methylated cytosine and/or adenine bases using electrical current cues from Oxford Nanopore sequencers.

In two studies, researchers sequenced nearly 500 tumors to uncover hallmarks of aggressive prostate cancer.

An analysis of copy number changes and genomic rearrangements in more than 100 tumors suggests chromothripsis may contribute to pancreatic cancer evolution.


Berkeley researchers have engineered yeast to make the molecule behind the hoppy taste of beer, Quartz reports.

King's College London researchers examine the influence of school type and genetics on academic achievement.

FiveThirtyEight writes that most who take a direct-to-consumer BRCA1/2 genetic test won't learn much from it.

In Science this week: early life experience influence somatic variation in the genome, and more.