NYGC
CRISPR Researchers Engineer Guide RNAs to Enhance Cas13 Gene Knockdown
The modified guide RNAs increased CRISPR editing efficiencies two- to fivefold over the editing efficiency achieved with unmodified guides, the researchers said.
Over the next year or so, the investigators plan to sequence the genomes of 3,000 patients with cancer, heart disease, diabetes, or neurological disorders.
CRISPR Screen Identifies Host Genes Needed for SARS-CoV-2 Infection, Potential Drug Targets
The screen homed in on a number of genes involved in cholesterol biosynthesis that, when lost, make cells more resistant to infection.
Algorithm Uncovers New Complex Rearrangement Classes in Cancer Genomes
Researchers found complex "rigma," "pyrgo," and "tyfona" structural variant classes by applying their new algorithm to thousands of cancer genomes.
GTEx Studies Provide Comprehensive Map of Genetic Regulatory Variation Across Cell Types, Tissues
The GTEx Consortium, which has been working for 10 years, analyzed how genetic variants affect gene regulation, and how this contributes to disease and traits.