NYGC CRISPR Researchers Engineer Guide RNAs to Enhance Cas13 Gene Knockdown The modified guide RNAs increased CRISPR editing efficiencies two- to fivefold over the editing efficiency achieved with unmodified guides, the researchers said. New York Study Aims to Assess Utility of Clinical Whole-Genome Sequencing Across Diseases Premium Over the next year or so, the investigators plan to sequence the genomes of 3,000 patients with cancer, heart disease, diabetes, or neurological disorders. CRISPR Screen Identifies Host Genes Needed for SARS-CoV-2 Infection, Potential Drug Targets The screen homed in on a number of genes involved in cholesterol biosynthesis that, when lost, make cells more resistant to infection. Algorithm Uncovers New Complex Rearrangement Classes in Cancer Genomes Researchers found complex "rigma," "pyrgo," and "tyfona" structural variant classes by applying their new algorithm to thousands of cancer genomes. GTEx Studies Provide Comprehensive Map of Genetic Regulatory Variation Across Cell Types, Tissues The GTEx Consortium, which has been working for 10 years, analyzed how genetic variants affect gene regulation, and how this contributes to disease and traits. Sep 9, 2020 NYGC Initiative Receives up to $2.1M for Cancer Studies in Ethnic Minorities Jun 12, 2020 Liquid Biopsy Startup C2i Genomics to Launch International Validation Trials for MRD Detection Tech Premium Apr 21, 2020 New York COVID-19 Genomics Research Network Coalesces to Battle Pandemic Mar 17, 2020 NYGC Researchers Develop CRISPR-Based Screen to Target RNA Viruses Like SARS-CoV-2 Premium Jan 24, 2020 New Method Captures Higher-Order Chromatin Contacts With Nanopore Sequencing Premium Nov 22, 2019 People in the News: Mary-Claire King, Patrick Finn, Milton Silva-Craig, More Oct 10, 2019 RNA-Seq Data Helps Focus Search for Rare Variants Aug 1, 2019 Single-Cell Method Could Eliminate Need for Mouse Models to Study Cancer Treatment Resistance Premium Jun 25, 2019 Consortium Sets Out to Bring Precision Medicine Approaches to Very Rare Cancers in NY Premium Jun 24, 2019 New York Genome Center Wins $1.5M Chan Zuckerberg Initiative Grant May 23, 2019 New York Genome Center Gets $125M Gift from Simons Foundation, Carson Family Charitable Trust May 15, 2019 Single-Cell Methylation Analysis Reveals CLL Evolution, Lineages With Distinct Treatment Responses Apr 26, 2019 Gencove Wins $330K NIH Grant for Polygenic Risk Score Evaluation Tech Apr 25, 2019 New York Genome Center Team Develops Multimodal Single-Cell Sequencing Assay Premium Apr 4, 2019 Spatial Transcriptomics Enables Researchers to Map Gene Expression During ALS Progression Feb 27, 2019 Weill Cornell, NYGC Group to Commercialize WGS Circulating Tumor DNA Cancer Recurrence Assay Premium Feb 4, 2019 New York Genome Center Receives $6M From ALS Association, Tow Foundation Dec 7, 2018 Cancer Whole-Genome and Transcriptome Test Expands NYGC's Clinical Services Premium Dec 5, 2018 Chan Zuckerberg Initiative Awards $52M in Grants for Neurodegenerative Disease Research Oct 18, 2018 BGI Americas, Gencove Partner on Sequencing Service Load More Breaking News IV BioHoldings Partners With P4 Diagnostix, Unveils 'Bio Innovation Studio' Polynesian Island Population History Revealed From Present-Day Human Genomes Aviv Scientific Closes $40M Series B Financing Round Roche Nabs CE Mark for Three Cobas Respiratory Test Panels Hexagon Bio Raises $61M in Private Financing Round GenXys, Helix Partner to Provide Clinical Decision Support for PGx Testing The Scan Not Yet a Permanent One NPR says the lack of a permanent Food and Drug Administration commissioner has "flummoxed" public health officials. Unfair Targeting Technology Review writes that a new report says the US has been unfairly targeting Chinese and Chinese-American individuals in economic espionage cases. Limited Rapid Testing The New York Times wonders why rapid tests for COVID-19 are not widely available in the US. Genome Research Papers on IPAFinder, Structural Variant Expression Effects, Single-Cell RNA-Seq Markers In Genome Research this week: IPAFinder method to detect intronic polyadenylation, influence of structural variants on gene expression, and more.