NICE UK's NICE Recommends Genetic Testing for Therapy Selection in Stroke Patients Clopidogrel is less effective at preventing subsequent strokes in patients with certain variations in the CYP2C19 gene and testing could aid treatment selection. NICE Recommends Genedrive Test in Draft Guidance to Prevent Hearing Loss in Newborns NICE recommended that Genedrive's MT-RNR1 ID Kit should be adopted by the NHS for the prevention of antibiotic-induced hearing loss. UK's NICE to Accelerate Assessment of Genedrive Test NICE plans to assess Genedrive's MT-RNR1 test for antibiotics-induced hearing loss in infants via a new program. Breast Cancer Molecular Tests Included in Recommendations by UK's NICE The group recommends Myriad Genetics' EndoPredict, NanoString's Prosigna, and Genomic Health's Oncotype DX tests for guiding chemotherapy decisions if certain conditions are met. UK's NICE Finalizing Updated Breast Cancer Test Guidance Following Stakeholder Comments Premium Although a draft guidance last month recommended against use of molecular tests to guide chemotherapy, the group's finalized decision is subject to price negotiation and other adjustments. Jan 10, 2018 NICE Draft Guidance Reverses Endorsement of Oncotype Dx to Guide Chemotherapy Feb 5, 2015 UK's NHS Adopts NICE Advice to Provide Oncotype DX for Intermediate Risk Breast Cancer Patients Nov 20, 2014 NHS Cancer Drug Fund Reevaluating Whether to Keep Providing Several Pricey Personalized Therapies Premium Feb 25, 2013 Most Viewed Articles on GWDN Last Week: Feb 25, 2013 Feb 20, 2013 In Preliminary Recommendation, UK's NICE Backs Oncotype DX in Subset of Breast Cancer Patients Premium Jan 23, 2013 UK's NICE Seeks Comments on Updated Guidelines for Familial Breast Cancer Genetic Testing, Treatment Premium Nov 2, 2012 UK Study Suggests VEGF Splice Isoform Ratio Could Predict Colorectal Cancer Patients' Avastin Response Premium Sep 12, 2012 During Investor Day, Roche Highlights Personalized Medicine as Key Area for Future Growth Premium May 2, 2012 Merck Serono Survey Finds Limited Test Access, High Costs a Barrier to Personalized Rx Adoption in UK Premium Feb 22, 2012 Lab21 Offering Companion Testing to Personalize ALK Inhibitors for NSCLC Patients Premium Feb 8, 2012 Breast Cancer Test Makers Will Attempt to Sway UK's NICE in Wake of Initial Negative Opinion Premium Oct 19, 2011 UK's NICE Cites Lack of Response Markers for BMS' Yervoy as Factor in Negative Recommendation Premium Jun 8, 2011 Q&A: NICE's Nick Crabb on Assessing Drugs and Diagnostics for the UK Medical System Premium Feb 23, 2011 NICE Agrees With FDA in Pulling Avastin's Indication for Metastatic Breast Cancer Premium Feb 16, 2011 Cancer Research UK on Path to Building National Genetic Testing Service Premium Aug 25, 2010 Despite PGx Leads, Avastin Access Debate Not Focused on Personalized Medicine Strategies Premium Jun 2, 2010 UK's NICE Backs Iressa Coverage at Fixed Price; NHS Pays for Genetic Testing Premium Apr 28, 2010 Resuscitation Uncertain: Can Debiopharm Help Revive Pfizer's Failed Melanoma Drug? Premium Apr 21, 2010 With New Hires to Pharma Business Development Team, Qiagen Prioritizes Rx/Dx Partnership Strategy Premium Apr 7, 2010 AstraZeneca Paying for Genetic Testing Services for UK Lung Cancer Patients Receiving Iressa Premium Breaking News Verily Awarded CDC Contract for Wastewater Surveillance Genomic Health to Pay $32.5M to Resolve Cancer Test False Claims Allegations by DOJ Vela Diagnostics Inks Japan Distribution Agreement for HIV-1 Drug Resistance Tests Coronary Artery Calcification Contributors, Potential Drug Targets Found in Cross-Ancestry GWAS Max Planck Team Uses Spatial Single-Cell Proteomics Method to Analyze Hepatocyte Heterogeneity The Scan Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. Small Study of Gene Editing to Treat Sickle Cell Disease In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema. Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.