Newcastle University
Mitochondrial Protein Resource Reveals New Disease Players
Researchers developed a "mitochondrial orphan protein multi-omics" (MITOMICS) app by profiling proteins, lipids, and metabolites in cells lacking individual mitochondrial proteins.
De Novo Mutations Linked to Male Infertility in Trio Exome Sequencing Study
At the ASHG annual meeting this week, a Newcastle University researcher described efforts to find de novo mutations behind oligozoospermia or azoospermia.
Blood, Immune Cell Formation in Fetal Bone Marrow Detailed in Cell Atlas Effort
The researchers found that blood and immune cells quickly diversify within fetal bone marrow, but that there are differences in Down syndrome samples.
Skin Cell Atlas Elucidates Pathological Cell States Underlying Inflammatory Skin Diseases
Researchers profiled the transcriptomes of more than 500,000 single cells from human fetal skin and adult skin with atopic dermatitis and psoriasis.
Nonalcoholic Fatty Liver Disease Progression Can Be Traced by Gene Expression Signature
A transcriptomic study found 25 genes that are differentially expressed at various disease stages, suggesting the proteins they encode could serve as biomarkers.