Teams from France and Germany disputed the notion that the 21-gene signature is needed to identify low-risk breast cancer patients who can be spared chemotherapy.
Researchers used the 21-gene expression assay to find individuals at lowest risk of breast cancer recurrence, who were spared adjuvant chemotherapy.
The funding will support work identifying the mechanisms underlying the differential responses among pediatric and adult ALL patients to therapy.
The patent application was filed by Montefiore Medical Center's Sanjay Goel and John Mariadason, who discovered the association between mutations in the PIK3CA and PTEN genes and a lack of response to EGFR inhibitors.
The technology from Montefiore Medical Center relates to tumor-specific mutations in the genes PIK3CA and PTEN that can be useful in predicting patient non-response to EGFR inhibitors.
Stephane Perrey, Kazuo Tokushige, Allen Bombard, Jorge Leon
Frank Witney, Allen Bombard
Ivanka Trump and Secretary of Education Betsy DeVos call on girls to pursue STEM careers, the Associated Press reports.
Some science companies will be taking part in next month's March for Science, Fortune reports.
In Genome Research this week: longitudinal study of Burkholderia cenocepacia isolates from cystic fibrosis patients, long-read assembly approach, and more.
Shale oil companies are turning to DNA sequencing to find spots to drill, Reuters reports.