Montefiore Medical Center
Single-Cell Sequencing Study Finds Increased Single-Nucleotide Mutation Rate in Lungs of Smokers
This mutation rate increased linearly until 23 pack-years of exposure before plateauing, suggesting there may be mechanisms limiting mutation accumulation.
The study, which is recruiting 1,130 children with undiagnosed genetic diseases, is testing two web-based interactive tools.
Algorithmic Approach Looks to Improve Identification of Misdiagnosis
A study led by Johns Hopkins describes a method for automating slow, inaccurate manual chart review when searching for signs of misdiagnosis.
Teams from France and Germany disputed the notion that the 21-gene signature is needed to identify low-risk breast cancer patients who can be spared chemotherapy.
Study Supports Prognostic Potential of Genomic Health's Oncotype DX in Breast Cancer
Researchers used the 21-gene expression assay to find individuals at lowest risk of breast cancer recurrence, who were spared adjuvant chemotherapy.