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MMRC

Consortium Reports on Findings from Multiple Myeloma Genomes

Based on their whole-genome or exome analyses of multiple myeloma samples from 38 individuals, members of the Multiple Myeloma Research Consortium have learned more about known pathways contributing to the disease and identified several previously unidentified genetic players.

Consortium Members Present Preliminary Results from Multiple Myeloma Genomic Effort

Researchers involved in the Multiple Myeloma Research Consortium Genomics Initiative reported on their initial sequence and copy number analyses of multiple myeloma genomes at the American Association for Cancer Research annual meeting this week.

Multiple Myeloma Genomics Initiative Completes Sequencing Genomes of First Tumor Samples
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The initiative, which involves the Broad Institute and the Translational Genomics Research Institute, aims to comprehensively analyze the genomes of 250 multiple myeloma samples. MMRF said this spring that as part of the project, the Broad would sequence the genomes of at least 50 of the tumors.

MMRF Completes Sequencing of Myeloma Genome

The multiple myeloma project will place the genomic data online.
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Harvard Team Report One-Time Base Editing Treatment for Motor Neuron Disease in Mice

A base-editing approach restored SMN levels and improved motor function in a mouse model of spinal muscular atrophy, a new Science paper reports.

International Team Examines History of North American Horses

Genetic and other analyses presented in Science find that horses spread to the northern Rockies and Great Plains by the first half of the 17th century.

New Study Examines Genetic Dominance Within UK Biobank

Researchers analyze instances of genetic dominance within UK Biobank data, as they report in Science.

Cell Signaling Pathway Identified as Metastasis Suppressor

A new study in Nature homes in on the STING pathway as a suppressor of metastasis in a mouse model of lung cancer.