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Fight, Fight, Fight!

The USPTO has become involved in the CRISPR-Cas9 patent dispute.

The patent office has named the Broad Institute, et al. as the junior party in the proceedings and the University of California, et al. as the senior party.

By coupling a microfluidic platform and RNA sequencing, researchers found that single cells belonging to the same lineage have similar transcriptomic profiles.

Feng Zhang has shown how to systematically find and improve CRISPR systems, but scientists haven't settled on how to evaluate them for clinical use.

Scientists from the Zhang laboratory have systematically interrogated the protein structure of Cas9 to optimize its genome editing specificity.

A study in Molecular Cell shows CRISPR-Cas9-like genome editing in human cells and suggests one protein could be an RNA-guided, RNA-cleaving endonuclease.

A method developed at MIT creates polyacrylamide beads around droplets containing single cells to sequester bacterial genomes and allow for harsh lysis conditions; it then uses concatenated PCR and sequencing to address links between phylogeny and function.

The court found that the university had failed to demonstrate that one of its researchers had collaborated with the IP's inventors and therefore is not entitled to co-inventorship.

Scientists at CSHL's Genome Engineering meeting offered their thoughts on the Zhang Lab's discovery published Friday in Cell.

James Collins and Shimyn Slomovic have created a modular system that could help research in gene editing, chromosomal structure, and cancer.

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A genetic genealogy analysis helped secure the release of a California man from prison after getting his murder conviction overturned, the Guardian reports.

Technology Review discusses the concerns that come along with the ability to quickly synthesize viruses like SARS-CoV-2.

Researchers have uncovered large bacteriophages whose genomes include translational machinery, Live Science reports.

In PNAS this week: role for Myc in alternative splicing regulation in prostate cancer, variation in methylation in Arabidopsis, and more.