Close Menu

MIT

Scientists from the Zhang laboratory have systematically interrogated the protein structure of Cas9 to optimize its genome editing specificity.

A study in Molecular Cell shows CRISPR-Cas9-like genome editing in human cells and suggests one protein could be an RNA-guided, RNA-cleaving endonuclease.

A method developed at MIT creates polyacrylamide beads around droplets containing single cells to sequester bacterial genomes and allow for harsh lysis conditions; it then uses concatenated PCR and sequencing to address links between phylogeny and function.

The court found that the university had failed to demonstrate that one of its researchers had collaborated with the IP's inventors and therefore is not entitled to co-inventorship.

Scientists at CSHL's Genome Engineering meeting offered their thoughts on the Zhang Lab's discovery published Friday in Cell.

James Collins and Shimyn Slomovic have created a modular system that could help research in gene editing, chromosomal structure, and cancer.

By editing a promoter of an enhancer of the mutated hemoglobin responsible for sickle cell disease, the researchers may have found a way to treat it.

The researchers demonstrated the ability to use one Cas9 enzyme for both genome editing and activating gene expression in the same cell.

Using epigenetic data, expression profiles, gene editing, and more, researchers uncovered interactions in fat precursor cells that may explain FTO's role in obesity.

MIT researchers have developed genetic parts that can be used to program gene expression in the commensal gut bacterium Bacteroides thetaiotaomicron.

Pages

A new report offers ways for small, society publishers to transition to Plan S standards, ScienceInsider says.

A gas explosion sparked a fire at a Russian laboratory that stores dangerous pathogens, the Guardian reports.

Researchers turn to protein analysis to examine an ancient rhino sample, Smithsonian.com reports.

In PNAS this week: C2CD4A gene involved in insulin secretion, chromosome rearrangements in recurring S. aureus infections, and more.