MIT
Programmable CRISPR-Based Tool 'Pastes' in New Genes While Avoiding Double-Strand Breaks
Researchers have developed a gene-editing tool called PASTE that combines properties of CRISPR and serine integrases and can insert sequences as large as 36 kilobases.
Global Biobank Meta-Analysis Initiative Brings Greater Diversity to Global GWAS
The initiative combines biobank data from around the globe to provide deeper and more representative insights into the genetics of human health.
Cancer Cell Line Screen Identifies Biomarkers Linked to Uptake of Therapeutic Nanoparticles
The nanoPRISM (profiling relative inhibition simultaneously in mixtures) assay uncovered an inverse relationship between SLC46A3 expression and uptake of liposomal nanoparticles.
Deep Learning Method Helps ID Cancer Drivers Based on Somatic Mutation Rates, Positive Selection
Using a computational method called Dig, researchers traced mutation rates in 37 cancer types, focusing on suspected driver mutations under positive selection across the genome.
Single-Cell Transcriptome Resource From Human Cell Atlas Team Yields Immune, Disease Insights
Researchers tallied expression features across hundreds of cell types with single-cell or -nucleus sequencing on hundreds of thousands of cells from numerous individuals.