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An unusually high number of off-target effects obtained during a screen suggested that “misleading results in siRNA screens using large libraries with single-assay readout is substantial.”

A review of the National Cancer Institute's online clearinghouse for clinical trial information shows that more than a dozen groups worldwide are either conducting or preparing to launch studies examining miRNA signatures in humans with a variety of diseases.

Through a two-stage GWAS study, an international research team tracked down variants that modify the breast cancer risk associated with BRCA2 mutations, showing that these overlap with other breast cancer risk variants.

The licensing agreement pertains to a patent describing the diagnostic use of a fluorescent-based, allele-specific PCR assay to amplify the V600E mutation.

The company plans to use the BRAF-related IP in a PCR-based assay that could be used to help inform cancer treatment decisions.

The research team analyzed a combination of DNA sequence, copy number, and mRNA expression to identify several genes associated with soft-tissue sarcoma subtypes.

American researchers reported today they have identified microRNA-mediated interactions between coding and non-coding messenger RNAs.

The hospital believes it is the first to receive approval from the state to use the instrument for diagnosing gene mutations.

Wendel and colleagues used a short hairpin library screen to identify genes whose knockdown mimicked the effect of microRNA-19, a member of the oncogenic miR-17-92 cluster, in lymphocytes, hypothesizing that this would reveal the genes responsible for the miRNA's activity.

The Institute for Systems Biology and MD Anderson Cancer Center are two of six research institutions selected as TCGA Genome Data Analysis Centers.


The Wall Street Journal looks into FamilyTreeDNA's handling of genetic genealogy searches by law enforcement.

In a point-counterpoint in the Boston Globe, researchers discuss the potential of gene editing to prevent Lyme disease, but also the pitfalls of doing so.

MIT's Technology Review reports that researchers hope to develop a CRISPR-based pain therapy.

In Science this week: atlas of malaria parasites' gene expression across their life cycles, and more.