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Memorial Sloan-Kettering

Paul Marks Dies

According to the New York Times, Paul Marks, the former president and chief executive of Memorial Sloan Kettering Cancer Center, has died at 93.

Using single-cell RNA sequencing, researchers identified cells in mouse and human prostate tissues that appear to help regrow the gland after prostate cancer treatment.

A new paper outlines an upcoming effort to trace tumor development and trajectory in time and space using single-cell genetics and other genomic methods.

A study of both tissue and blood samples from patients in a small trial found that liquid biopsy may detect putative resistance mutations missed in tissue.

A new analysis suggests hypermutation can occur in some chemotherapy-treated gliomas, producing heterogeneous, mutation-rich tumors with poor response to anti-PD-1 treatment.

In PLOS this week: yeast modeling of mutations found through MSKCC IMPACT, tumor features associated with presence of circulating DNA, and more.

In Nature this week: new and efficient CRISPR system, chromatin interaction profiles improves prediction of brain disorder risk genes, and more.

Patients undergoing allogeneic hematopoietic stem cell transplants who had less diverse gut microbiomes had a higher risk of death, a study found.

The OpenNotes movement is encouraging experimentation as some health systems start making complete genomic reports available to patients the moment the lab signs off. 

Clonal hematopoiesis variants appear to outnumber tumor mutations in the plasma of most cancer patients, the investigators found in their study.

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New analyses indicate female researchers are publishing less during the coronavirus pandemic than male researchers, according to Nature News.

A study suggests people with the ApoE e4 genotype may be more likely to have severe COVID-19 than those with other genotypes, the Guardian says.

Direct-to-consumer genetic testing companies are searching for a genetic reason for why some people, but not others, become gravely ill with COVID-19, the Detroit Free Press reports.

In PNAS this week: forward genetics-base analysis of retinal development, interactions of T cell receptors with neoantigens in colorectal cancer, and more.