Memorial Sloan-Kettering AACR Presentations Highlight Power of Large Tumor Atlases in Studies of Cancer Progression Premium The talks focused on studies stemming from the Cancer Moonshot initiative's Human Tumor Atlas Network project, which is readying its first data release. Genome Sequencing Identifies Myeloma Precursor Disease With High Progression Risk Investigators flagged a set of myeloma-defining genomic events that marked precursor conditions that were prone to morph into multiple myeloma. MSK Study Underscores Need to Validate Cancer-Specific Tumor Mutational Burden Cutoffs Premium A TMB-high cutoff of 10 mutations per megabase doesn't predict immunotherapy responses universally well across cancer types, according to a paper published in JAMA Oncology. MSK Team Explores Clinical Utility of Germline Testing for Pediatric Cancer Patients The researchers found that 18 percent of pediatric cancer patients tested with MSK-IMPACT harbored one or more inherited risk mutation. Clinicians Face New Intervention Questions as Clonal Hematopoiesis Mutation Data Evolves Premium Increased incidental detection of clonal hematopoiesis and new considerations for mutations in myelodysplastic precursors herald improved precision medicine strategies. Nov 18, 2020 MSK Study Suggests Germline Tests May Miss Mosaic Cancer Risk Mutations in Some Patients Premium Oct 29, 2020 Single-Cell Analysis Elucidates Mutation Patterns in Myeloid Malignancies Oct 27, 2020 Clonal Hematopoiesis Mutation Study Reveals Risk of Treatment-Related Cancer Oct 7, 2020 Immunotherapy Response Prediction Improved by Baseline, On-Treatment Biomarker Combo Premium Sep 18, 2020 MSK Clonal Hematopoiesis Clinic Aims to Drive New Strategies for Cancer Risk Assessment, Prevention Premium Sep 17, 2020 New York City Opening Dedicated COVID-19 Testing Laboratory Sep 10, 2020 Epic Sciences, MSK Identify Potential Prostate Cancer Therapy Response Biomarker Premium Sep 4, 2020 Mutations in FOXA1 Gene Can Affect Breast Cancer Patients' Response to Therapy Jul 1, 2020 Polygenic Risk Score Modifies Breast Cancer Risk in Pathogenic Variant Carriers Jun 11, 2020 'Very Fast' CRISPR Enables Immediate, Synchronous Cleavage of Genomic Sites May 31, 2020 Germline Results From Tumor-Normal Sequencing Guides Precision Therapy in Advanced Cancer Patients May 31, 2020 Polygenic Risk Score, Family History Refine Breast Cancer Risk Assessment in CHEK2 Mutation Carriers Apr 30, 2020 Prostate Cells With Regenerative Capability Uncovered by Single-Cell Transcriptomics Apr 16, 2020 Human Tumor Atlas Network Team Shares Strategy for Tracking Tumor Transitions Apr 15, 2020 Guardant360 Results in Alpelisib Trial Suggest Liquid Biopsy May Help Better Capture Non-Responders Premium Apr 15, 2020 Glioma Hypermutation May Not Correspond to Checkpoint Immunotherapy Response, Study Suggests Feb 27, 2020 Microbiome Composition Predicts Clinical Outcome Among Stem Cell Transplant Patients Feb 11, 2020 Healthcare Providers Try New Ways to Share Genetic Test Results With Patients, but Pitfalls Remain Premium Nov 27, 2019 MSK Study With Expanded Liquid Biopsy Panel Supports Value of Tumor-Normal Sequencing Premium Nov 19, 2019 Double Mutations in PIK3CA Gene Increase Patient Sensitivity to Targeted Therapies, Study Finds Premium Load More Breaking News Enzo Biochem, CLX Health Partner to Support COVID-19 Testing for International Travel Type 1 Diabetes GWAS, Fine-Mapping Leads to New Genetic Loci, Potential Drug Targets LSU Health Sciences Center Wins $2.4M to Lead SARS-CoV-2 Variant Sequencing Program NanoString Technologies, Parker Institute for Cancer Immunotherapy Partner on Cell Therapy Project BGI Americas Collaborating With Champions Oncology on Proteomic Cancer Research Personal Genome Diagnostics Inks Cancer Genomic Profiling Deal with Duke University Health System The Scan Missed Early Cases A retrospective analysis of blood samples suggests early SARS-CoV-2 infections may have been missed in the US, the New York Times reports. Limited Journal Editor Diversity A survey finds low diversity among scientific and medical journal editors, according to The Scientist. How Much of a Threat? Science writes that need for a provision aimed at shoring up genomic data security within a new US bill is being questioned. PNAS Papers on Historic Helicobacter Spread, Brain Development, C. difficile RNAs In PNAS this week: Helicobacter genetic diversity gives insight into human migrations, gene expression patterns of brain development, and more.