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Alterations affecting the antigen presentation-related gene B2M appeared to be over-represented in melanomas with checkpoint blockade non-response or resistance.

The initiative's four research projects will use use genetic and other technologies to detect and treat cancer at its earliest stages.

A new set of papers reveals a range of gene expression influencers, identified using thousands of samples collected for the Genotype-Tissue Expression project.

Verge is working with four academic institutions to create a broad resource for the translation of preclinical models of amyotrophic lateral sclerosis research.

The newly announced Microbiome Immunity Project seeks to discover links between autoimmune diseases and bacteria in and on the human body.

The collaborators have signed a two-year research and license option agreement to develop novel T-cell therapies for cancer using genome editing technology.

The partners aim to develop a diagnostic methodology for obtaining cancer cell molecular profiles to help guide immunotherapies.

Or Maybe OK

A new BioRxiv preprint says the variants another research team attributed to off-target effects of CRISPR/Cas9 could be natural variation, New Scientist reports.

LASSO probes

The approach, published earlier this week in Nature Biomedical Engineering, uses long-adapter single-strand oligonucleotide (LASSO) probes.

The two studies describe methods for identifying off-target mutations associated with cell-type-specific SNPs and detecting potential off-target cleavage sites.

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Researchers have developed a robotic lab assistant, the Verge reports.

CBC News reports Canada's Supreme Court is to rule on the constitutionality of the country's genetic non-discrimination law today.

The Associated Press reports the World Health Organization is sending experts to China to investigate the animal source of SARS-CoV-2.

In Science this week: atlas of affected cell populations in idiopathic pulmonary fibrosis, and more.