In a study of more than 300,000 participants, middle-aged individuals with a high polygenic score weighed nearly 30 pounds more on average than those with lower scores.
Researchers found that both CBEs and ABEs can cause transcriptome-wide RNA edits, which has implications for the research and therapeutic uses of base editors.
The agriculture company said it will use the technology it has licensed for new applications in crop editing and for research to bring new foods to market.
In Cell this week: somatic mtDNA mutation-based "genetic barcode" method, molecular mechanisms behind structural variants at 17p11.2, and more.
Researchers defined six malignant cell clusters with single-cell transcriptomes and genotypes for thousands of acute myeloid leukemia cells.
Using data for more than a million individuals with or without insomnia, two independent research teams tracked down associated risk loci and explored their functional effects.
Researchers used a genome-wide association study to identify seven loci associated with ASD and other conditions, along with five loci linked to ASD alone.
In Nature this week: genomic factors that influence glioblastoma response to anti-PD-1 therapy, sequencing test for infectious disease, and more.
The team engineered an enhanced Acidaminococcus sp. Cas12a variant that has the ability to target many previously inaccessible protospacer adjacent motifs.
The article argues that PRS are bad at identifying those who will develop disease but others say this is the same for widely used risk factors.
Forensic genetic firm Verogen has bought the genetic genealogy site GEDmatch.
Researchers have 3D-printed plastic bunnies that encase the information needed to make more such bunnies in DNA, according to Discover magazine.
Dan Rather, the former CBS Evening News anchor and executive producer of a new documentary, writes at the Guardian that everyone needs to know about CRISPR.
In PNAS this week: analysis of FOXA1 upregulation in ER-positive breast cancer, gene editing to correct recessive dystrophic epidermolysis bullosa, and more.