The researchers believe that combining liquid and tissue biopsy can improve diagnostic and therapeutic options for cancer patients with acquired drug resistance mutations.
The team found that base editors that exhibit RNA off-target editing can also self-edit their own transcripts, leading to heterogeneity in their coding sequences.
Researchers identified five loci that were overrepresented in individuals with past, self-reported same-sex sexual behavior, though the associations were complex.
The program, launched last year, is designed to help early-career investigators who have primarily worked within groups pursuing independent research.
Using single-cell RNA-seq and other approaches, researchers looked at the four known medulloblastoma subtypes and the brain cell types from which they arise.
A proof-of-principle study suggests metabolite clusters may differ in non-small cell lung cancer patients depending on tumor type, disease stage, and overall survival trajectory.
The Boston Globe reports that increased genetic screening of healthy people can make returning disease risk findings tricky.
In PNAS this week: mathematical model of metastatic seeding, mitochondrial mutation effects, and more.
Researchers tracked down monogenic risk variants, carriers, disease culprits, and more for 50 individuals with cardiomyopathy and 50 unaffected participants.
Investigators used gene panel sequence data to look at rare de novo variant frequencies in potential risk genes for neurodevelopmental disorders with epilepsy.
The Washington Post reports that a Russian Academy of Sciences commission has led to the retraction of hundreds of scientific papers.
The Los Angeles Times' Daily Pilot reports the chief executive of Vantari Genetics has pleaded guilty in a kickback scheme.
News 4 Jax reports that a Florida bill to prevent life and long-term care insurers from using genetic information in their coverage decisions has easily passed one committee.
In Science this week: potentially pathogenic mutations found in hematopoietic stem cells from young healthy donors, and more.