Mass General New Approach Aims to Improve Polygenic Risk Score Predictions Across Ancestries Premium The method, dubbed PRS-CSx, integrates summary statistics from genome-wide association studies of multiple populations to generate a polygenic risk score. Clinical Polygenic Risk Assay, Reporting Pipeline Shows Promise for Multiple Conditions Premium Researchers developed assays to assess PRSs for six common conditions, along with methods for sharing the results with doctors and patients. Genomic Study of Mammalian Species Links Somatic Mutation Rate to Lifespan By sequencing multiple samples from more than a dozen mammalian species, investigators uncovered an inverse relationship between a species' lifespan and somatic mutation rate. Schizophrenia, Bipolar Disorder Risk Traced to Common, Rare Variants in New Genetic Studies Researchers found that rare and common genetic risk factors for schizophrenia discovered in the two studies converged on many of the same biological mechanisms. UK Biobank Exome Study Uncovers Rare Variants Contributing to Cardiometabolic Disease, Traits Researchers flagged 57 genes linked to cardiovascular or metabolic traits or conditions, including Mendelian disease genes and genes impacted by common variants. Feb 14, 2022 Cardiometabolic Disease Shows Ties to Depressive Mood, Irrespective of Genetic Risk Oct 27, 2021 Polygenic Risk Scores Edge Toward Clinic, Though Disease Prediction Utility Questions Linger Premium Oct 22, 2021 SUPER Psychosis Study Presented at ASHG Digs Into Relationships of Rare Variants, Phenotypes Oct 12, 2021 BostonGene Helping MassGeneral Improve Understanding of Follicular Lymphoma Progression, Treatment Oct 11, 2021 Protective, Risk-Linked APOE Alleles Affect Glial Cell Transcriptome Oct 7, 2021 Lung Cancer Treatment Response Linked to Cancer-Associated Fibroblast Cell Subtypes Aug 5, 2021 Lung Cancer Features, Treatment Clues Emerge From 'Omic Analysis of Difficult-to-Treat Subtype Jun 8, 2021 NIH Earmarks $38M for Consortium Studying Polygenic Risk Scores in Diverse Populations May 7, 2021 Guardant MRD Test Performs Well in Small Study as Tissue-Informed Debate Takes Shape Premium Apr 19, 2021 ACMG Presentation Highlights Broad Institute's Massive Expansion of COVID-19 Testing Program Apr 8, 2021 Long-Read Genome Assemblies Have 'Blind Spots' for Structural Variant Detection Premium Apr 2, 2021 Alzheimer's Disease Genomes Lead to Novel Loci Involved in Synaptic Function Feb 9, 2021 European Project Sets Out to Harness Genomics Data, AI to Create New Predictive Tools Premium Feb 1, 2021 Interpace, Rutgers, Mass General Sign Deal for Pancreatic Cyst Risk Assessment Biomarker Oct 28, 2020 Finnish Population Genomics Study Uncovers Rare, Recessive Disease Candidates Premium Aug 27, 2020 Natera, MGH to Collaborate in Early-Stage Breast Cancer Clinical Trial of Targeted Therapy Aug 20, 2020 Polygenic Variation Affects Disease Risk From Monogenic Variants, Study Finds Jul 20, 2020 New CRISPR Base Editors Induce Targeted DNA Transversions Premium Jul 9, 2020 Integrated Proteomic Papers Define Lung Cancer Features Across Populations, Smoking Histories Jun 30, 2020 Fluxergy, Mass General Brigham Partner to Evaluate Rapid COVID-19 Molecular Testing System Load More Breaking News People in the News at Pacific Biosciences, Metabolon, NeoGenomics, More New Products Posted to GenomeWeb: Tethis, Invitae, PerkinElmer, More In Brief This Week: Thermo Fisher Scientific, Bruker, Quantum-Si, BioMérieux, More Luminex Obtains CE Marking for MDx Panel to Detect Flu A/B, RSV, COVID-19 Palmetto Finalizes Positive LCD for Prostate Cancer Risk Tests Gene Expression, Histology Reveal Clues for Targeted Rheumatoid Arthritis Treatment The Scan Call for a Different Tack Experts weigh the value of recent experiments testing genetically modified pig kidneys using brain-dead individuals, according to Nature News. Wastewater Warning The New York Times reports that wastewater surveillance in some parts of the US point to a possible surge. Can't Get in the Program Due to the Northern Ireland protocol dispute, the European Union is preventing UK researchers from joining the Horizon Europe research program, the Times of London reports. Science Paper on Spatial-Controlled Genome Editing In Science this week: approach to enable a CRISPR-Cas13a-based system to be used as a cancer therapy.