A team compared expression in duodenum samples from active celiac cases, cases in remission, and unaffected controls, identifying active disease-related expression shifts.
In a study of more than 300,000 participants, middle-aged individuals with a high polygenic score weighed nearly 30 pounds more on average than those with lower scores.
Researchers found that both CBEs and ABEs can cause transcriptome-wide RNA edits, which has implications for the research and therapeutic uses of base editors.
The agriculture company said it will use the technology it has licensed for new applications in crop editing and for research to bring new foods to market.
Using data for more than a million individuals with or without insomnia, two independent research teams tracked down associated risk loci and explored their functional effects.
Researchers used a genome-wide association study to identify seven loci associated with ASD and other conditions, along with five loci linked to ASD alone.
The team engineered an enhanced Acidaminococcus sp. Cas12a variant that has the ability to target many previously inaccessible protospacer adjacent motifs.
St. Jude Children's Research Hospital scientists have treated infants with X-linked severe combined immunodeficiency using gene therapy in an early phase study.
In Nature this week: a genomic analysis of the snailfish Pseudoliparis swirei, ancient DNA analysis gives insight into the introduction of farming to England, and more.
