Mass General NIH Earmarks $38M for Consortium Studying Polygenic Risk Scores in Diverse Populations The consortium aims to develop and evaluate methods for calculating polygenic risk scores for specific diseases, particularly for people of different ancestries. Guardant MRD Test Performs Well in Small Study as Tissue-Informed Debate Takes Shape Premium The data, while limited, indicate that the firm's blood-only assay may be able to match the performance of existing commercial tissue-informed competitors. ACMG Presentation Highlights Broad Institute's Massive Expansion of COVID-19 Testing Program The Broad's clinical research sequencing lab now runs 135,000 tests each day and routinely tests more than 100 higher education sites and 40 schools in the state. Long-Read Genome Assemblies Have 'Blind Spots' for Structural Variant Detection Premium Researchers comparing structural variant detection using short- and long-read technologies said assembly-based methods can provide added value, despite missing certain CNVs. Alzheimer's Disease Genomes Lead to Novel Loci Involved in Synaptic Function Starting with genome sequences for thousands of individuals from Alzheimer's-affected families, researchers found rare disease-associated variants at 13 new loci. Feb 9, 2021 European Project Sets Out to Harness Genomics Data, AI to Create New Predictive Tools Premium Feb 1, 2021 Interpace, Rutgers, Mass General Sign Deal for Pancreatic Cyst Risk Assessment Biomarker Oct 28, 2020 Finnish Population Genomics Study Uncovers Rare, Recessive Disease Candidates Premium Aug 27, 2020 Natera, MGH to Collaborate in Early-Stage Breast Cancer Clinical Trial of Targeted Therapy Aug 20, 2020 Polygenic Variation Affects Disease Risk From Monogenic Variants, Study Finds Jul 20, 2020 New CRISPR Base Editors Induce Targeted DNA Transversions Premium Jul 9, 2020 Integrated Proteomic Papers Define Lung Cancer Features Across Populations, Smoking Histories Jun 30, 2020 Fluxergy, Mass General Brigham Partner to Evaluate Rapid COVID-19 Molecular Testing System Jun 11, 2020 Diversity Problem Hinders Adoption of Polygenic Risk Scores, According to ESHG Panel Jun 1, 2020 CRISPR Researchers Develop Dual-Deaminase Base Editing Platforms May 27, 2020 GnomAD Consortium Details Range of Human Genetic Variation From Large Dataset May 11, 2020 Day Zero Diagnostics Using CARB-X Award to Commercialize Antibiotic-Resistance Testing Platform Premium May 8, 2020 Dilated Cardiomyopathy Risk Loci, Polygenic Score Emerge From Heart Imaging GWAS May 6, 2020 Chan Zuckerberg Initiative Grants $750K to COVID-19 Studies Using Single-Cell Methods Apr 16, 2020 Biogen Launches Employee COVID-19 Biobank With Broad Institute, Partners HealthCare Apr 6, 2020 Mass General, CHOP, Northwestern Med Get FDA EUAs for SARS-CoV-2 Tests Mar 26, 2020 MGH Researchers Develop Nearly PAMless CRISPR-Cas9 Variant Mar 16, 2020 Mass General, Brigham and Women's Open Clinics to Integrate Genomics Into Primary Care Premium Jan 29, 2020 Breast Cancer Risk Clues Found By Sequencing Cells From BRCA2 Germline Mutation Carriers Jan 8, 2020 Obesity Polygenic Risk Score Relatively Poor Predictor of Midlife BMI in Longitudinal Study Load More Breaking News BTIG Initiates Coverage of Berkeley Lights With Buy Rating Quest Diagnostics to Offer Biocept's Target Selector NGS Lung Cancer Test Novacyt 2020 Revenues Surge on Strong Demand for SARS-CoV-2 Testing Products Leidos Wins CDC Bioinformatics Contract Worth up to $13M Thermo Fisher Scientific Next-Generation SARS-CoV-2 PCR Test Nabs CE-IVD Mark Cytosine Base Editor Enables Genome-Wide Genetic Function Screening The Scan Renewed Gain-of-Function Worries The New York Times writes that the pandemic is renewing concerns about gain-of-function research. Who's Getting the Patents? A trio of researchers has analyzed gender trends in biomedical patents issued between 1976 and 2010 in the US, New Scientist reports. Other Uses CBS Sunday Morning looks at how mRNA vaccine technology could be applied beyond SARS-CoV-2. PLOS Papers Present Analysis of Cervicovaginal Microbiome, Glycosylation in Model Archaea, More In PLOS this week: functional potential of the cervicovaginal microbiome, glycosylation patterns in model archaea, and more.