Kyoto University
Compact Gene Editing Enzyme May Improve Success Rates of Gene Therapies
The newly developed gene editor has 10 times more editing ability than the original unmutated gene editing enzyme, AsCas12f.
Refined Picture of Breast Cancer Clone Evolution Emerges from Phylogenetic Study
Researchers from Japan sequenced the genomes of cancer and non-cancer lesions from the same patients to map the evolution of breast cancer cells.
Machine Learning Tool Uncovers Novel Endogenous Viruses in Human Genome
Researchers from Kyoto University in Japan said the newly uncovered sequences may reflect ancient viruses and give insight into viral diversity.
Coronary Artery Disease Loci Identified in Japanese GWAS, Trans-Ancestry Meta-Analysis
Researchers found ancestry-specific risk variants and developed a better polygenic risk score based on a GWAS and subsequent meta-analysis.
Cancer Driver Gene Mutations Rise with Age in Otherwise Normal Esophageal Tissue
DNA sequence data from hundreds of individuals suggest that age, smoking, and alcohol use coincide with the expansion of clones containing NOTCH1 and PPM1D mutations.