A subset of mutation-associated neoantigens appeared to be lost from lung or head and neck tumors that became resistant to anti-PD1 or anti-PD1 and anti-CLTA4 therapy.
A Johns Hopkins University team developed a framework to evaluate approaches to predicting cancer driver genes.
In PNAS this week: transcriptional control enables malaria parasite to get around disease control efforts, DNA methylation patterns in the Norway spruce, and more.
The technology, which is patent pending, can be used to help identify cancer patients who would respond to immune checkpoint inhibition treatment.
In Nature this week: modern European bison analysis, phased diploid genome assembly algorithms, and more.
Researchers from Pacific Biosciences and elsewhere tested their approach on Arabidopsis thaliana before applying it to wine grape and coral fungus genomes.
The model could shift which patients receive gene expression profiling assays but might not change the number of tests ordered.
Using data from the Simons Simplex Collection, researchers estimated that 5 percent of autism spectrum disorder cases may involve mosaic de novo mutations.
The Albert and Mary Lasker Foundation has announced this year's recipients of its prizes honoring basic and clinical research.
Researchers found that mutations in this gene increased the risk of chronic obstructive pulmonary disease, bone marrow failure, and other conditions.
In Science this week: deletion of one microRNA allows pluripotent stem cells to form embryonic and non-embryonic lineages, and more.
Arizona is planning to sue Theranos for "deceptive acts" and misrepresentations of its "capabilities and operation."
If confirmed as Department of Health and Human Services Secretary, Tom Price says he will divest himself of certain holdings, according to Stat News.
Oliver Smithies, who won the Nobel Prize in 2007, has died, the New York Times reports.