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Johns Hopkins

Single-Cell RNA Isoform Sequencing Picks up Steam as Long-Read Technologies Improve
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Recent advancements in long-read sequencing are enabling researchers to study full-length mRNA isoforms at the single-cell level.

Johns Hopkins Team Using Long-Read Sequencing to Crack Genetic Code of Pancreatic Cancer
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Funded by the Lustgarten Foundation, the researchers plan to analyze 400-plus pancreatic cancer samples to study the genetic changes linked to the disease.

AGBT Sessions Shine Spotlight on Long-Read Sequencing
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Long-read sequencing featured prominently in many of the talks at this year's Advances in Genome Biology and Technology meeting.

Liver Cancer Detection Score Developed With Machine Learning Analysis of Blood Plasma DNA Fragments

Researchers used machine learning to come up with a cell-free DNA 'fragmentome'-based score for finding hepatocellular carcinoma cases from blood plasma samples.

Haystack Oncology to Debut Hypersensitive Residual Cancer Test Based on Hopkins Tech
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The company is aiming to launch clinical testing services by the second half of next year, using a high-sensitivity, patient-personalized assay technology.

Nov 16, 2022

Liquid Biopsy Startup Haystack Oncology Raises $56M in Series A Round

Nov 1, 2022

Johns Hopkins Team Develops Isothermal PCR Method Using Novel Helicase
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Oct 27, 2022

Immunotherapy Response Features Identified in Pancreatic Cancer Microenvironment

Oct 20, 2022

CRISPR Screens Identify Potential Host Targets to Reverse HIV-1 Latency

Jul 1, 2022

New Cas9 Enrichment Method Improves Targeted Nanopore Sequencing
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Jun 7, 2022

Circulating Tumor DNA Utility in Post-Surgery Stage II Colon Cancer Cemented by New Data
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May 2, 2022

Genetic Study in Different Ancestries Offers Insight into Plasma Protein Regulation

Mar 31, 2022

New Esophageal Cancer Tests on Horizon as Hopkins Spinout Capsulomics Preps Clinical Launch
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Mar 23, 2022

GeneMatcher Team Plans Improvements for Researchers, Patients to Build on Recent Successes
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Mar 8, 2022

Bipolar Disorder Study Finds Role for Gene Expression Changes Affecting Nerve Synapses 

Oct 28, 2021

Researchers Force Nanopore Sequencing to Go Short-Read for Copy Number Analysis in Cancer
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Oct 20, 2021

Telomere-To-Telomere Consortium Shares Insights From Gapless Human Genome at ASHG
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Sep 30, 2021

National Disease Research Interchange, Collaborators Win $12.5M NIH Grant for Biospecimen Effort

Sep 28, 2021

New Leukocyte-Linked Loci Uncovered With Multi-Ancestry Genomes

Jul 2, 2021

Astronomy, Biology Come Together for Cancer Biomarker Discovery
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Jun 10, 2021

Rockefeller Foundation Funds Global Pathogen Sequencing With $20M, Forms Collaborations

Apr 29, 2021

Valted Seq Lands Exclusive Rights to Evaluate Johns Hopkins Neurodegenerative Disease Dx Assays

Mar 10, 2021

Polygenic Risk Score Reporting Standards Developed

Feb 10, 2021

ImmunoScape, Johns Hopkins Team Profiles T Cell Response in COVID-19 Patients
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Jan 27, 2021

Heart Transplant Cell-Free DNA Test Enables Earlier Detection of Acute Rejection Than Biopsy
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The Scan

Study Examines Insights Gained by Adjunct Trio RNA Sequencing in Complex Pediatric Disease Cases

Researchers in AJHG explore the diagnostic utility of adding parent-child RNA-seq to genome sequencing in dozens of families with complex, undiagnosed genetic disease.

Clinical Genomic Lab Survey Looks at Workforce Needs

Investigators use a survey approach in Genetics in Medicine Open to assess technologist applications, retention, and workforce gaps at molecular genetics and clinical cytogenetics labs in the US.

Study Considers Gene Regulatory Features Available by Sequence-Based Modeling

Investigators in Genome Biology set sequence-based models against observational and perturbation assay data, finding distal enhancer models lag behind promoter predictions.

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.