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This Week in PNAS

In PNAS this week: mutation patterns in uterine and ovarian carcinosarcomas, deep genome sequences, and more.

Researchers studying the sequence data of individuals from a range of populations uncovered new sequences, variants, and variant-intolerant sites.

Diving in Deep

In a preprint, Craig Venter's team reports sequencing the genomes of 10,500 people to between 30X and 40X coverage.

The Human Immunome Program, which is part of the Human Vaccines Project, eventually plans to profile B-cell and T-cell receptors in more than 1,000 individuals.

This Week in Science

In Science this week: minimal bacterial genome of just 473 genes, and more.

Craig Venter and his colleagues develop a minimal bacterial genome of 473 genes, though the function of a third of those genes is unknown.

By sequencing and comparing pathogenic, intermediate, and saprophytic Leptospira species, researchers uncovered genes and pathways with potential ties to infection.

Researchers put together an almost 2-billion-base genome assembly for the deer tick, which can transmit pathogens causing Lyme disease and other conditions.

Single-molecule sequencing of A. baumannii and Enterobacter species is uncovering the context and mechanics of antibacterial resistance.

NEW YORK (GenomeWeb) – Using a synthetic biology-based approach, researchers from the J. Craig Venter Institute and Kansas State University found that a bat influenza virus uncovered in 2009 poses little-to-no pandemic threat to humans.

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In Science this week: metagenomic-based technique for determining protein structure, and more.

An academic laments the rise of narcissism in the sciences, the Guardian reports.

Outgoing FDA commissioner Robert Califf writes in an editorial that the agency can help boost innovation.

The Trump transition team has asked NIH Director Francis Collins to remain at his post, though it's unclear for how long that will be.