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Jackson Lab

Clinicians found interpreting negative results and variants of uncertain significance to be challenging, according to an analysis presented at the NSGC annual meeting.

Microsoft is applying its Project Hanover AI to Jackson Laboratory's Clinical Knowledgebase to help tumor boards find appropriate therapies based on tumor mutations.

The study used a variety of sequencing and mapping technologies, including from Illumina, Pacific Biosciences, 10X Genomics, Bionano Genomics, and Oxford Nanopore.

With single-cell RNA-seq on thousands of cells from the lateral hypothalamic area of male and female mice, researchers saw dozens of glutamatergic and GABAergic neuron types.

New Mice for the Job

Researchers have developed a new Alzheimer's disease mouse model with greater genetic diversity.

The projects are organized by the Eliminate Cancer Initiative, the National Brain Tumor Society, and the Pediatric Brain Tumor Foundation.

Researchers used CRISPR to engineer mice that have multiple genetic variants associated with late-onset AD to facilitate research into biomarkers and treatments.

The Jackson Laboratory scientists are aiming to create a molecular toolkit that allows for the precise and reversible manipulation of epigenetic modifications.

Jackson Laboratory is re-creating the genome of the female mouse from which its line of C57BL/6J mice descends, according to Nature News.

Participants in the pilot will begin developing the capabilities required for the planned data commons, including making data transparent and interoperable.

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A small, early-stage trial of a combination therapy for brain cancer reports favorable responses in two patients, according to the Guardian.

Nature News writes that viral genomic surveillance in the US faces systemic issues.

President Joe Biden is seeking an increase in federal spending, including higher budgets for the National Institutes of Health and Centers for Disease Control and Prevention.

In PLOS this week: sex-stratified genome-wide association study of chronic pain, sequencing data from Indigenous Mexican groups, and more.