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Institut Pasteur

In PNAS this week: autosomal genes commonly affected by loss-of-function variants, variants implicated in testis development disorders, and more.

Based on mouse and human data, researchers focused on hypermethylated genes in blood samples from individuals with colorectal cancer and gut dysbiosis.

The new test uses the number of sequencing reads at specific early and late HPV transcripts as a biomarker for high-grade cytology.

The team will create a group called the Extracellular RNA Communication Consortium Stage 2 to develop new EV-based technology and treat diseases.

Researchers analyzed more than 550 new and previously sequenced exomes for individuals from African rainforest hunter-gatherer and farming populations, searching for local adaptations.

Researchers identified 34 known and 30 new Leptospira species by sequencing dozens of isolates from soil and water samples in Asia, Africa, Europe, and Oceania.

In PNAS this week: retinitis pigmentosa gene therapy, role of microbiome in growth stunting, and more.

In PLOS this week: sequences influencing yeast prion aggregation or degradation, dengue virus genetic variants affect transmission dynamics, and more.

The researchers conducted a genome-wide association study and other analyses using about 47,000 research participants from 23andMe.

By sequencing Vibrio cholerae isolates from Africa and Latin America, investigators got a look at the lineages leading to outbreaks over several decades.

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The Washington Post reports that Herbert Tabor, who worked at the US National Institutes of Health for 77 years, has died at 101.

The World Bank is seeking approval for a $12 billion plan to provide low-income nations with funds to procure SARS-CoV-2 vaccines, according to Reuters.

Science writes that public health officials and others are debating whether cycle threshold values should be included on SARS-CoV-2 results.

In Nucleic Acids Research this week: online database of SARS-CoV-2 protein structures, atlas of the human brain, and more.