INSERM | GenomeWeb


A proteomic analysis of pancreatic ductal adenocarcinoma tumor and stromal samples led to a stromal protein that appears to coincide with tumor aggressiveness.

The initiative, launched last year by Quest and the French National Institute of Health and Medical Research, has reclassified 375 variants of unknown significance so far.

Ranomics is building a business around providing functional data on variants of unknown significance, starting with BRCA1 mutations.

Using data from more than 800 colorectal cancer samples, researchers concluded that features in the microenvironment may protect against metastasis.

A French team sequenced and compared Streptococcus agalactiae isolates from 19 mothers and their infected infants.

The field needs a database that can help inform variant classifications reported to patients, but Quest finds most publicly available resources aren't robust enough for this purpose.

In joining forces to support BRCAShare, Quest and LabCorp are taking on Myriad Genetics, which maintains a proprietary database with more than 1 million test results.

An INSERM-led team has uncovered new hepatocellular carcinoma mutational signatures that reflect exposure to certain disease risk factors.

The technology compensates for genomic DNA amplified in qPCR gene expression measurements.

The signatures involve a panel of genes that help researchers to distinguish between benign and malignant liver tumors and identify histological subtypes


In Science this week: convergent evolution in bird hemoglobin, and more.

The Wall Street Journal speaks with patients affected by questionable test results from Theranos.

Researchers link variants in TACR3 to hot flashes during menopause, Live Science reports.

Kuwait says it will alter its law requiring citizens and visitors to provide DNA samples, New Scientist reports.