Indiana University

With its inaugural informatics director set to begin next month, the year-old IU Precision Health Initiative should begin its research work this fall.

Changes Required

A culture change is needed to make science more reproducible, says Indiana's Aaron Carroll at the New York Times.

A chromosome 15 variant may have ties to congenital heart failure in breast cancer patients who receive treatment with the anthracycline chemotherapy doxorubicin.

Indiana University researchers said that insights into this mechanism could lead to finding treatment targets for both diseases.

The method works by adding noise to database search results to confound algorithms that try to access private details about contributing individuals.

The results support a survival benefit for patients treated with therapies guided by combined DNA and mRNA sequencing and protein expression analyses. 

The initiative is being funded under the university's Grand Challenges Program, which aims to promote research that will benefit communities across the state.

The web-based gene analysis software is now implemented on IU's NCGAS resources and will soon be running on hardware at other XSEDE network sites.

Individuals who failed to clear a bacterial infection had variable skin microbiomes before exposure to the bug, but converged on similar skin microbiomes afterwards.

In a 6,000-patient study, Eskenazi Health will assess whether PGx testing improves outcomes and saves money in a community that doesn't usually have access to genomic advances.

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Using DNA to sketch crime victims might not be a great idea, the NYTimes says.

Science has its own problem with sexual harassment. What do we do with the research these abusers produce, Wired asks.

Senate Republicans led by Senator Rand Paul (R-KY) are trying to change how the government funds basic research, reports ScienceInsider.

In Science this week: combining genomics and ecology to better understand the effects of natural selection on evolution, and more.