A chromosome 15 variant may have ties to congenital heart failure in breast cancer patients who receive treatment with the anthracycline chemotherapy doxorubicin.
Indiana University researchers said that insights into this mechanism could lead to finding treatment targets for both diseases.
The method works by adding noise to database search results to confound algorithms that try to access private details about contributing individuals.
The results support a survival benefit for patients treated with therapies guided by combined DNA and mRNA sequencing and protein expression analyses.
The initiative is being funded under the university's Grand Challenges Program, which aims to promote research that will benefit communities across the state.
The web-based gene analysis software is now implemented on IU's NCGAS resources and will soon be running on hardware at other XSEDE network sites.
Individuals who failed to clear a bacterial infection had variable skin microbiomes before exposure to the bug, but converged on similar skin microbiomes afterwards.
In a 6,000-patient study, Eskenazi Health will assess whether PGx testing improves outcomes and saves money in a community that doesn't usually have access to genomic advances.
The 6,000-patient study will investigate whether using PGx testing to guide treatment with 33 medications improves patient outcomes and reduces costs.
The last paragraph of this article has been corrected to note that the $150 million in funding is in support of the Strategic Research Initiative.
In Science this week: intellectual property landscape of CRISPR genome editing, and more.
A researcher has been convicted of conspiring to steal genetically engineered rice, Reuters reports.
Harvard Medical School's George Church says a woolly mammoth-elephant hybrid is only a few years away, according to the New Scientist.
Intel is ending its sponsorship of the International Science and Engineering Fair, the New York Times reports.