ICR Guardant AACR Data Highlights Value of Clinical Test Database to Drive Drug Resistance Discoveries Researchers used the company's large clinical-genomic database to characterize HRD reversion mutations and explore their potential function in patient resistance to PARP inhibitors. Integrated Proteomic Papers Define Lung Cancer Features Across Populations, Smoking Histories Three research teams profiled proteomic, genomic, and other features in lung adenocarcinomas in Asia and other parts of the world, including cases in never-smokers. RB1 Alterations in Advanced Prostate Cancer Associated With Poor Outcome Using exome or transcriptome data from more than 400 metastatic, castration-resistant prostate cancer cases, researchers identified survival-related alterations in the RB1 gene. UK Group Develops Cancer Liquid Biopsy Assay to Detect Low-Level Mutations Premium The group plans to use the assay for translational studies on metastasis and drug resistance initially and to develop a clinical version later on. Chromosome Interactions at Promoters Reveal Non-Coding Colorectal Cancer Mutations Researchers found relevant non-coding mutations in colorectal cancer cell lines by systematically profiling chromosome interactions at promoter fragments. Sep 13, 2018 GWAS Links Six New Loci to Multiple Myeloma Risk, Uncovers Potential Mechanisms Jul 2, 2018 Cooperation Among Pediatric Brain Cancer Tumor Cell Subpopulations Boosts Tumorigenic Ability Jun 11, 2018 Prostate Cancer Meta-Analysis Leads to New Risk Loci, Polygenic Risk Score Jun 6, 2018 Prostate Cancer Study Suggests Patients With DNA Repair Mutations May Benefit From Immunotherapy May 14, 2018 Children With Specific Brain Tumors Could Benefit From Added Bevacizumab Apr 30, 2018 Study Links BRCA1/2 Germline Mutations to Platinum Drug Response in TNBC Apr 9, 2018 Multiple Myeloma Study Links More Than Three Dozen Genes to Disease Mar 12, 2018 Breast Cancer Risk Gene Candidates Revealed by Chromosome Interaction Profiling Mar 7, 2018 Clinical Trial Results Support Liquid Biopsy Monitoring to Predict Responders to Palbociclib Premium Dec 1, 2017 Hodgkin Lymphoma GWAS, Meta-Analysis Leads to Immune-Related Loci Sep 28, 2017 Pediatric Glioma Splintered Into Distinct Subgroups by Molecular Meta-Analysis Jun 23, 2017 Liquid Biopsy May Guide PARP Inhibitor Therapy for Prostate Cancer Premium Jun 12, 2017 New Testicular Cancer Markers Revealed in Studies Jun 1, 2017 Landscape Still Unclear for Prostate Cancer Therapy Prediction Tests as New Approaches Emerge Premium Dec 20, 2016 Some Testicular Cancer Cases Involve Rare Ciliary Gene Mutations Jun 22, 2016 Rare Colorectal Cancer Risk Variants ID'd in Exome Sequencing Study Apr 7, 2016 Royal Marsden, ICR Launch Pilot to Sequence Pediatric Cancer Patients' Tumors Premium Jan 8, 2016 GWAS Yields Locus Linked to Multiple Myeloma Survival Oct 27, 2015 UK Study Uncovers Four New Testicular Germ Cell Tumor Risk Loci Oct 1, 2015 Meta-Analysis Links Five New Variants to Brain Cancer Risk Load More Breaking News Alzheimer's Disease Phosphoproteomics Study Uncovers Signaling Abnormalities Genetic Analysis of H. Pylori Indicates Americas Colonized in One Main Migration Event BillionToOne Raises $55M in Series B Financing GeninCode to Launch Cardiovascular Disease Risk Tests in US With Eversana Top Five Articles on GenomeWeb Last Week: Illumina, Liquid Biopsy, Thermo Fisher Scientific, and More Becton Dickinson Sues Beckman Coulter Over Cell Analysis, Sorting IP The Scan Another Resignation According to the Wall Street Journal, a third advisory panel member has resigned following the US Food and Drug Administration's approval of an Alzheimer's disease drug. Novavax Finds Its Vaccine Effective Reuters reports Novavax's SARS-CoV-2 vaccine is more than 90 percent effective in preventing COVID-19. Can't Be Used The US Food and Drug Administration says millions of vaccine doses made at an embattled manufacturing facility cannot be used, the New York Times reports. PLOS Papers on Frozen Shoulder GWAS, Epstein-Barr Effects on Immune Cell Epigenetics, More In PLOS this week: genome-wide association study of frozen shoulder, epigenetic patterns of Epstein-Barr-infected B lymphocyte cells, and more.