Logo

ICR

Genetic, Epigenetic Factors Alongside Phenotypic Plasticity Influence Colorectal Cancer Evolution

A pair of papers examined sequencing, transcriptomic, and chromatin accessibility within colorectal cancer samples to tease out how the tumors evolve.

Guardant AACR Data Highlights Value of Clinical Test Database to Drive Drug Resistance Discoveries

Researchers used the company's large clinical-genomic database to characterize HRD reversion mutations and explore their potential function in patient resistance to PARP inhibitors.

Integrated Proteomic Papers Define Lung Cancer Features Across Populations, Smoking Histories

Three research teams profiled proteomic, genomic, and other features in lung adenocarcinomas in Asia and other parts of the world, including cases in never-smokers.

RB1 Alterations in Advanced Prostate Cancer Associated With Poor Outcome

Using exome or transcriptome data from more than 400 metastatic, castration-resistant prostate cancer cases, researchers identified survival-related alterations in the RB1 gene.

UK Group Develops Cancer Liquid Biopsy Assay to Detect Low-Level Mutations
Premium

The group plans to use the assay for translational studies on metastasis and drug resistance initially and to develop a clinical version later on.

Sep 17, 2018

Chromosome Interactions at Promoters Reveal Non-Coding Colorectal Cancer Mutations

Sep 13, 2018

GWAS Links Six New Loci to Multiple Myeloma Risk, Uncovers Potential Mechanisms

Jul 2, 2018

Cooperation Among Pediatric Brain Cancer Tumor Cell Subpopulations Boosts Tumorigenic Ability

Jun 11, 2018

Prostate Cancer Meta-Analysis Leads to New Risk Loci, Polygenic Risk Score

Jun 6, 2018

Prostate Cancer Study Suggests Patients With DNA Repair Mutations May Benefit From Immunotherapy

May 14, 2018

Children With Specific Brain Tumors Could Benefit From Added Bevacizumab

Apr 30, 2018

Study Links BRCA1/2 Germline Mutations to Platinum Drug Response in TNBC

Apr 9, 2018

Multiple Myeloma Study Links More Than Three Dozen Genes to Disease

Mar 12, 2018

Breast Cancer Risk Gene Candidates Revealed by Chromosome Interaction Profiling

Mar 7, 2018

Clinical Trial Results Support Liquid Biopsy Monitoring to Predict Responders to Palbociclib
Premium

Dec 1, 2017

Hodgkin Lymphoma GWAS, Meta-Analysis Leads to Immune-Related Loci

Sep 28, 2017

Pediatric Glioma Splintered Into Distinct Subgroups by Molecular Meta-Analysis

Jun 23, 2017

Liquid Biopsy May Guide PARP Inhibitor Therapy for Prostate Cancer
Premium

Jun 12, 2017

New Testicular Cancer Markers Revealed in Studies

Jun 1, 2017

Landscape Still Unclear for Prostate Cancer Therapy Prediction Tests as New Approaches Emerge
Premium

Dec 20, 2016

Some Testicular Cancer Cases Involve Rare Ciliary Gene Mutations

Jun 22, 2016

Rare Colorectal Cancer Risk Variants ID'd in Exome Sequencing Study

Apr 7, 2016

Royal Marsden, ICR Launch Pilot to Sequence Pediatric Cancer Patients' Tumors
Premium

Jan 8, 2016

GWAS Yields Locus Linked to Multiple Myeloma Survival

Oct 27, 2015

UK Study Uncovers Four New Testicular Germ Cell Tumor Risk Loci

Breaking News
The Scan

Nucleotide Base Detected on Near-Earth Asteroid

Among other intriguing compounds, researchers find the nucleotide uracil, a component of RNA sequences, in samples collected from the near-Earth asteroid Ryugu, as they report in Nature Communications.

Clinical Trial Participants, Investigators Point to Importance of Clinical Trial Results Reporting in Canadian Study

Public reporting on clinical trial results is crucial, according to qualitative interviews with clinical trial participants, investigators, and organizers from three provinces appearing in BMJ Open.

Old Order Amish Analysis Highlights Autozygosity, Potential Ties to Blood Measures

Researchers in BMC Genomics see larger and more frequent runs-of-homozygosity in Old Order Amish participants, though only regional autozygosity coincided with two blood-based measures.

Suicidal Ideation-Linked Loci Identified Using Million Veteran Program Data

Researchers in PLOS Genetics identify risk variants within and across ancestry groups with a genome-wide association study involving veterans with or without a history of suicidal ideation.