Genetic, Epigenetic Factors Alongside Phenotypic Plasticity Influence Colorectal Cancer Evolution
A pair of papers examined sequencing, transcriptomic, and chromatin accessibility within colorectal cancer samples to tease out how the tumors evolve.
Guardant AACR Data Highlights Value of Clinical Test Database to Drive Drug Resistance Discoveries
Researchers used the company's large clinical-genomic database to characterize HRD reversion mutations and explore their potential function in patient resistance to PARP inhibitors.
Integrated Proteomic Papers Define Lung Cancer Features Across Populations, Smoking Histories
Three research teams profiled proteomic, genomic, and other features in lung adenocarcinomas in Asia and other parts of the world, including cases in never-smokers.
RB1 Alterations in Advanced Prostate Cancer Associated With Poor Outcome
Using exome or transcriptome data from more than 400 metastatic, castration-resistant prostate cancer cases, researchers identified survival-related alterations in the RB1 gene.
The group plans to use the assay for translational studies on metastasis and drug resistance initially and to develop a clinical version later on.