Icahn School of Medicine Multiple Myeloma Patient Similarity Network Reveals Prognostically Informative Subgroups Researchers identified 12 multiple myeloma subgroups based on mutation, copy number, chromosomal rearrangement, and expression features in more than 650 tumors. Cancer Genomic Analysis Reveals Distinct Features in Tumors From Patients Under 50 Years Old Researchers saw distinct driver mutation, tumor microenvironment features, and more when they compared tumors from dozens of cancer types in patients younger or older than 50. Microbes Behind Successful Fecal Microbiota Transplantations May Become Basis for New Treatments With microbial sequencing data for FMT donors and recipients, researchers defined which bugs take up long-term residence in recipient guts. Alzheimer's Disease Subtypes Proposed From Gene Expression Profiles of Brain Regions Investigators identified five expression subtypes spanning three broader clusters in postmortem parahippocampal gyrus samples from Alzheimer's patients. IBD Polygenic Risk Scores Improved With Data From Multiple Ancestral Backgrounds The researchers also examined the contribution of rare variants to inflammatory bowel disease to find a potential targetable pathway. Nov 25, 2020 Pediatric Brain Tumor Proteomics Highlight Possible Treatment Targets, Biomarkers Nov 20, 2020 People in the News: New Appointments at Natera, Quanterix, Sophia Genetics, More Oct 29, 2020 Helio Heath Aims to Market Blood-Based Liver Cancer Screening Assay in Early 2021 Premium Oct 16, 2020 SARS-CoV-2 Protein Interaction Study Reveals Key Proliferation Pathways, Possible Drug Targets Premium May 7, 2020 Fluidigm Q1 Revenues Fall 8 Percent Mar 16, 2020 Mount Sinai-Led Consortium, Fluidigm Developing Epigenetic Coronavirus Dx Jan 23, 2020 Autism Sequencing Study Uncovers New Disease-Associated Genes, Functional Clues Jun 13, 2019 Mount Sinai Gets $27.8M DARPA Grant for Epigenetic Tech to Measure WMD Exposure May 1, 2019 Bipolar Disorder Risk Loci Reported From Psychiatric Genomics Consortium GWAS Apr 30, 2019 PCOS Traits Tied to Rare Variants in Testosterone-Related Gene Mar 25, 2019 Schizophrenia Genes, Pathways in Brain Identified With Transcriptome Imputation Approach Dec 13, 2018 PsychENCODE Studies Explore Brain Development, Neuropsychiatric Regulatory Features Oct 18, 2018 Mount Sinai Researchers Develop Protein Barcoding Technology for Single-Cell CRISPR Screening Oct 8, 2018 Transcriptome Analyses Link Alzheimer's Disease With Brain Gene Splicing, Expression Aug 13, 2018 Mt. Sinai Researchers Use Multi-Omics Approach to Personalize Relapsed Multiple Myeloma Treatment Jul 25, 2018 Sleep, Depression Appear to Involve Shared Gene Networks Jun 21, 2018 Systems Biology Study of Alzheimer's Disease Supports Ties to Virus Dec 5, 2017 Acute Peanut Allergy Contributors Suggested by Blood Transcriptomic Study Sep 26, 2017 Autism Heritability Estimate Updated in New Analysis of 2014 Swedish Study Nov 23, 2016 Loci Linked to Body Shape Emerge From Composite Phenotype GWAS Meta-Analysis Load More Breaking News Biocartis Receives FDA 510(k) Clearance for Sepsis Assay DNA Script Receives CE Mark for Syntax Enzymatic DNA Synthesis Platform Exact Sciences, Pfizer End Cologuard Copromotion Agreement Genetron Health Q3 Revenues up 36 Percent, Firm Announces AstraZeneca MRD Partnership BioMark Diagnostics, AstraZeneca, Pfizer, Others Partner in Lung Cancer Screening Project Akoya Receives CLIA Certification for Biopharma Solutions Laboratory The Scan Looking for Omicron NPR reports that SARS-CoV-2 testing in the US has gotten better but also that some experts say more needs to be done to better track the Omicron variant. Holmes Alleges Abuse The Associated Press reports that Theranos' Elizabeth Holmes has testified at her wire fraud trial that her business and romantic partner abused her. Bit More Diverse, But More to Do While Black and Hispanic patients are more likely to participate in cancer clinical trials than previously, they are still underrepresented, according to US News & World Report. PNAS Papers on Yeast Gene Silencing, Zika Virus Inhibition, Immunoglobulin Hypermutation In PNAS this week: gene silencing in Saccharomyces cerevisiae, possible neuroprotective role for SHFL in a mouse model of Zika virus infection, and more.