HUPO

The 2010s saw major strides made through several large-scale initiatives aimed at mapping the human proteome and developing approaches for clinical work.

Gathering last week in Australia, the community continued its years-long push towards increased clinical relevance and integration with other omics disciplines.

The group's meeting this week evidenced the ongoing shift towards analyzing proteins in the context of specific isoforms, complexes, and cells.

The group has identified proteins from nearly 90 percent of the predicted protein-coding genes, though the remaining 10 percent present significant challenges.

Mirroring developments in the field more generally, the organization's annual meeting showed a move toward more applied research as well as multi-omic projects.

In a recent study, project researchers highlighted the need to use findings from outside proteomics as they chase down the remaining unidentified proteins.

Among the launches at the organization's annual meeting this week in Taipei were a personalized proteomics initiative and a new DIA mass spec method.

Writing in MCP, the researchers provided a survey of techniques for biologists interested in using multiplexed quantitative proteomics in their research.

The researchers will use the expressed proteins to refine and optimize multiple-reaction monitoring assays that they will then apply to actual biological samples.