After going through a restructuring phase at the end of last year in which it temporarily laid off its entire staff, LightSpeed continues to develop its optical detection technology and plans to test it with a new sequencing chemistry this year.
Both groups published methods that use padlock probes to target large numbers of loci containing CpG sites. In addition, one group developed a genome-wide approach that relies on a methylation-sensitive restriction enzyme.
Dana-Farber Cancer Institute's Center for Cancer Computational Biology, GenoLogics, Johns Hopkins National Heart, Lung and Blood Institute Proteomics Center, AstraZeneca, BioWisdom, Physiomics, Eli Lilly, Applied Biosystems, Golden Helix
Looking at approximately 326,000 SNPs in 1,053 Swedish subjects, the study is thought to be the first "sufficiently powered" trial to detect genome-wide significance of three SNPs. As a result, study authors note that "additional genes having a major influence on warfarin dose might not exist or be found in the near-term."