Garvan Institute of Medical Research Sarcoma Susceptibility Traced to Telomere Function, Mitotic Pathways A search for rare sarcoma-related germline variants led to centromere and shelterin genes involved in mitotic function and telomere regulation, respectively. Triple-Negative Breast Cancer Treatment Hints Drawn From Single-Cell Study Tumor microenvironment cell transcriptomes pointed to four stromal cell clusters, including immune interacting support cells predicted to impact immunotherapy response. GnomAD Consortium Details Range of Human Genetic Variation From Large Dataset The collection of more than 125,000 exomes and 15,000 genomes has enabled an analysis of loss-of-function variants, may help diagnose rare disease, and guide drug development. Genomes of Healthy Elderly Show Fewer Disease-Linked Variants The Medical Genome Reference Bank, which currently holds data for more than 2,500 healthy elderly Australians, could help scientists understand the genetics of healthy aging. Mitochondrial DNA Analysis Uncovers Human 'Homeland' in Southern Africa By combining mitochondrial DNA and climatic data, an international team of researchers found that an early mitochondrial lineage emerged in a paleo-wetland. Nov 28, 2018 Australian Clinical Labs, Garvan Institute Ink Pathology Services Deal Oct 24, 2018 Genome Sequencing Data From Thousands of Healthy Elderly People Now Available Sep 7, 2018 Garvan Institute Taps Dell to Expand Infrastructure for High-Throughput Genomic Analysis Premium Jul 27, 2018 Garvan Institute Building Case for WGS as First-Line Test for Some Genetic Disorders Premium Jul 19, 2018 Garvan Institute's Australian Genomic Cancer Medicine Program Receives A$50M in Government Funding Jun 26, 2018 Clearbridge Health Inks Deal to Promote Genome.One Personalized Genomics Service Oct 10, 2017 Garvan Partners With Blockchain Startup for Genomic Records Management Jul 5, 2017 OneOme, Genome.One Partner to Offer Genetic Risk, PGx Service in Australia Dec 21, 2016 Garvan Institute Launches Medical Genome Reference Bank to Help Inform Disease Variant Studies Premium Oct 31, 2016 BioNano Genomics Pushing Genome Mapping Technology Into Human Research Market Premium Sep 26, 2016 Investigators Weigh Nitty Gritty of Sequencing Costs, Question $1,000 Genome Premium Aug 16, 2016 Garvan Institute Sequencing 1,000 Genomes Per Month Premium Jul 29, 2016 DNAnexus Adds Garvan's Genome.One to Clinical Dx Client Roster Premium Jul 27, 2016 Australia's Garvan Institute Forms Startup to Offer Whole-Genome Sequencing Service May 18, 2016 Whole-Genome Sequencing Has Better Dx Rate Than Exome at Similar Cost, Australian Team Finds May 12, 2016 Weill Cornell, Garvan Institute Agree to Share Cancer Germline and Somatic Mutation Data Premium Sep 24, 2015 Garvan Institute, Genomics England Partner on Genomic Medicine Data Management Feb 23, 2015 Garvan Institute Taps DNAnexus Platform to Support Sequencing Services Feb 3, 2015 Australian Researchers Use Epigenetics to Stratify Triple Negative Breast Cancers Oct 20, 2014 Personalis, Garvan Institute to Provide Genome Sequencing, Analysis to Researchers, Clinicians Load More Breaking News SARS-CoV-2 Variants of Concerns Evolved to Modify Host Immune Response, Multiomics Study Shows People in the News at GA4GH, Mercy BioAnalytics, Deepcell, One Biosciences New Products Posted to GenomeWeb: Clinical Microbiomics, Integra Biosciences, DNAstack, Bruker Angolan Namib Desert Population Analysis Uncovers New Ancestry Group With Deep Divergence Cedars-Sinai Sets Up $25M Single Cell Precision Medicine Center The Scan Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. Small Study of Gene Editing to Treat Sickle Cell Disease In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema. Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.