Fred Hutchinson Cancer Research Center
Exome sequencing of more than 17,000 men with prostate cancer identified known and novel gene variants linked to risk of aggressive disease.
Study Explores Role of Prostate Cancer Mutations in 3' Untranslated Regions
Researchers at Fred Hutch used massively parallel reporter assays and CRISPR base editing to understand the impact of 3'UTR somatic mutations in prostate cancer.
Esophageal Cancer, Precancer Study Points to Extrachromosomal DNA Appearance
By analyzing precancerous Barrett's esophagus samples, researchers found that oncogene-containing extrachromosomal DNA may contribute to cancer transformation.
Multiomic Study Points to New Colorectal Cancer Risk Contributors
Researchers tracked down more than 100 new risk variants with a combination of genomic, transcriptomic, and methylation analyses, highlighting new and known risk pathways.
Breast, Ovarian Cancer Study Finds Ties Between Types of BRCA Alterations, Treatment Response
Breast and ovarian cancers with BRCA1 promoter methylation changes showed poorer chemotherapy responses than those with genetic alterations in BRCA1 or BRCA2.