Francis Crick Institute
Ancient Wolf Genomes Reveal Ice Age Population Connections, Clues to Origins of Dogs
Based on dozens of ancient wolf genomes, researchers detected genetic connectedness during the Ice Age and proposed at least two wolf sources of dog domestication.
Lupus Linked to TLR7 Mutations, Related Signaling Changes
Gain-of-function mutations in TLR7 were found to cause systemic lupus erythematosus through excess TLR7 pathway activation, pointing to possible treatment targets.
Cancer Genome Analysis Points to Biallelic Mutations to Inform Variant Interpretation
Investigators saw mutations affecting both maternal and paternal alleles in 21 percent of tumors in a pan-cancer collection, including mutations reflecting a tumor's mutagenic history.
Kidney Cancer Study Links Checkpoint Immunotherapy Responses to T Cell Features
Researchers from the UK used integrated genomics to analyze prospectively collected samples from metastatic clear cell renal cell carcinoma patients.
New Approach Uncovers Somatic Mutations in Non-Unique Genome Regions of Cancer Samples
The previously hidden mutations affected known cancer genes as well as immunoglobulins and other highly mutated gene families.