Francis Crick Institute Ancient Wolf Genomes Reveal Ice Age Population Connections, Clues to Origins of Dogs Based on dozens of ancient wolf genomes, researchers detected genetic connectedness during the Ice Age and proposed at least two wolf sources of dog domestication. Lupus Linked to TLR7 Mutations, Related Signaling Changes Gain-of-function mutations in TLR7 were found to cause systemic lupus erythematosus through excess TLR7 pathway activation, pointing to possible treatment targets. Cancer Genome Analysis Points to Biallelic Mutations to Inform Variant Interpretation Investigators saw mutations affecting both maternal and paternal alleles in 21 percent of tumors in a pan-cancer collection, including mutations reflecting a tumor's mutagenic history. Kidney Cancer Study Links Checkpoint Immunotherapy Responses to T Cell Features Researchers from the UK used integrated genomics to analyze prospectively collected samples from metastatic clear cell renal cell carcinoma patients. New Approach Uncovers Somatic Mutations in Non-Unique Genome Regions of Cancer Samples The previously hidden mutations affected known cancer genes as well as immunoglobulins and other highly mutated gene families. Apr 7, 2021 Intra-Tumor Heterogeneity of Dozens of Cancer Types Characterized Oct 29, 2020 Ancient Dog Genomes Highlight Close Relationship Between Canines, Humans May 26, 2020 AstraZeneca, ArcherDx Partner on Minimal Residual Disease Monitoring for Lung Cancer Drug Trials Mar 19, 2020 Human Genetic Variation, Population History Gleaned From Hundreds of Diverse Genomes Mar 28, 2019 ArcherDx, University College London, Crick Institute Partner on Lung Cancer Recurrence Research Dec 14, 2018 Genome Editing Patterns Could Help Predict CRISPR Outcomes Breaking News Simple HealthKit Raises $8M in Series A Round Top Five Articles on GenomeWeb Last Week: Quantum-Si Layoffs, UBS Coverage Initiations, More LumiraDx Secures FDA Emergency Use Authorization, UK Approval for COVID-19, Flu Test Rarity Bioscience Raises Additional €500,000 Cancer Prognoses Informed by Module-Based Approach, Study Finds The Scan UK Team Presents Genetic, Epigenetic Sequencing Method Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers. DNA Biobank Developed for French Kidney Donors, Recipients The KiT-GENIE biobank described in the European Journal of Human Genetics contains DNA samples, genotyping profiles, immune patterns, and clinical features for thousands of kidney donors or transplant recipients in Nantes, France. Cardiometabolic Disease May Have Distinct Associations With Microbial Metabolites in Blood, Gut By analyzing gut microbes in combination with related metabolites in feces and blood, researchers in Nature Communications found distinct cardiometabolic disease relationships at each site. Study Reveals New Details About Genetics of Major Cause of Female Infertility Researchers in Nature Medicine conducted a whole-exome sequencing study of mote than a thousand patients with premature ovarian insufficiency.