ETHZ

By a GenomeWeb staff reporter
NEW YORK (GenomeWeb News) – Swiss proteomics firm Biognosys has raised CHF2.7 million ($3 million) in a Series A round, it announced on Monday.

The project will involve several sequencing technologies, including Pacific Biosciences' PacBio RS.

By looking at microRNA profiles in two mouse models of obesity, researchers have identified a pair of closely related miRNAs that are involved in regulating glucose metabolism and insulin signaling.

Using a systems biology approach, researchers from Switzerland and the US have identified epistatic interactions involving mutations in two HIV-1 enzymes that can help predict the virus' ability to replicate in the presence or absence of more than a dozen drugs.

Using the strategy, which is under development as a biomarker discovery platform at ETH Zurich spin-off firm ProteoMedix, the researchers have identified four protein biomarkers tied to prostate cancer.

The European Bioinformatics Institute, Quretec, and at the Swiss Federal Institute of Technology Zurich have all joined the consortium.

The study offers scientists a streamlined method for investigating the effects of miRNAs on protein expression and is "quite typical" of the kind of work the ISB and ETH Zurich's SRMAtlas will help facilitate, said Ruedi Aebersold, co-developer of the SRMAtlas.

The new workflow, which is being developed on AB Sciex's QTRAP 5500 instrument, could reduce the time needed to conduct metabolomics analyses by up to ten-fold, said one of the scientists.

The partnership will focus on developing quantitative, broad-coverage, high-throughput metabolomics for systems biology using AB Sciex's mass spec technology.

Under the Phenotypic Drug Discovery program, researchers from academia or biotech submit candidate compounds in specific therapeutic areas for Lilly to evaluate and profile. Participating organizations retain full IP rights to the compounds, but Lilly receives first rights to negotiate a broader collaboration or licensing agreement.

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New results from the NASA Twins Study indicate that the immune system may rev up when in space, the Washington Post reports.

Kelvin Droegemeier, the new science advisor, spoke at the American Association for the Advancement of Science meeting, Geekwire reports.

In PNAS this week: whole-genome assembly for the white shark, paper-based microfluidic method for detecting the malaria parasite, and more.

The World Health Organization has announced the members of its gene-editing committee, according to NPR.