DKFZ
Mutational Signatures Profiled in Pediatric Cancers
Researchers uncovered and analyzed mutational signatures in 27 cancer types or subtypes by analyzing genome sequences for nearly 800 tumors.
Neuroblastoma Study Reveals Rearrangements Originating From Extrachromosomal Circular DNA
A sequencing study suggests circularized DNA may be a more common source of somatic rearrangements in neuroblastoma than previously appreciated.
Glioblastoma Driver Mutations Appear Long Before Diagnosis, Evolutionary Analysis Suggests
Molecular features in primary and recurrent glioblastomas indicated that key initiator mutations turned up years before diagnosis, often persisting in recurrent tumors.
DNA Methylation Data Helps Refine Classification of Central Nervous System Tumors
The researchers used DNA methylation profiles to define 82 central nervous system tumor classes, some of which differed from WHO tumor classes.
The team aims to release the new resource sometime next year, with the hope that it will become as widely used as other institute databases.
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