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Called optiPRM, the approach could help detect cancer neoantigens in patient tumor samples for applications like the development of personalized cancer vaccines.
German Children's Cancer Center Aims to Expand Global Access to Methylation-Based Tumor Classifier
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The program will provide funding and expertise to clinics in low-income countries to run methylation array-based assays to classify central nervous system tumors in children.
Mutational Signatures Profiled in Pediatric Cancers
Researchers uncovered and analyzed mutational signatures in 27 cancer types or subtypes by analyzing genome sequences for nearly 800 tumors.
Neuroblastoma Study Reveals Rearrangements Originating From Extrachromosomal Circular DNA
A sequencing study suggests circularized DNA may be a more common source of somatic rearrangements in neuroblastoma than previously appreciated.
Glioblastoma Driver Mutations Appear Long Before Diagnosis, Evolutionary Analysis Suggests
Molecular features in primary and recurrent glioblastomas indicated that key initiator mutations turned up years before diagnosis, often persisting in recurrent tumors.