The study showed that targeted sequencing was feasible, identified many clinically relevant alterations, and directed effective targeted therapy in several cases.
The study also found that esophageal squamous cell carcinomas resemble head and neck cancer, while esophageal adenocarcinomas are similar to gastric cancers.
Using sequencing approaches, researchers are learning more about what drives breast cancer metastasis and resistance.
The partners aim to create a broad collection of high-quality genomic and clinical data from multiple myeloma patients to improve disease diagnosis, prognosis, and treatment.
Exome and transcriptome sequences uncovered features that characterized testicular germ cell tumors by whether they did or did not respond to treatment.
Using two guide RNAs to excise chunks of the genome, an international team identified lncRNAs essential and inhibitory to human cancer cell line proliferation.
The lead investigators said that Foundation Medicine's NGS test will enable the beginning of targeted treatment within seven days of diagnosis.
The large-scale study is designed to advance personalized medicine for pancreatic cancer to help meet the organization's goal of doubling patient survival rates by 2020.
Having sequenced close to 15,000 samples, the project is now taking steps toward integrating results fully into patient medical records.
The Albert and Mary Lasker Foundation has announced this year's recipients of its prizes honoring basic and clinical research.
In Science this week: metagenomic-based technique for determining protein structure, and more.
An academic laments the rise of narcissism in the sciences, the Guardian reports.
Outgoing FDA commissioner Robert Califf writes in an editorial that the agency can help boost innovation.
The Trump transition team has asked NIH Director Francis Collins to remain at his post, though it's unclear for how long that will be.