Dana-Farber

At Bio-IT World, Harvard bioinformatics researcher John Quackenbush called typical methods for determining genetic relevance relics of "Mendel and his peas."

Shared gastric adenocarcinoma tumor features seem to span geography and ethnicity, despite shifts in the proportion of tumors from different molecular subtypes.

One speaker cited the success of screening Ashkenazi Jewish women for BRCA mutations, but another said extending testing to a wider population could be harder.

The developers said such a signature could help triage people exposed to radiation through war, a terrorist attack, or an industrial accident.

Researchers identified mutations present prior to allogeneic hematopoietic stem cell transplantation that coincided with MDS survival and relapse.

Alterations to Target

Researchers find that genetic testing of pediatric brain cancer can uncover clinically relevant alterations, Technology Review reports.

The results of the Harvard-led study suggest that the immune system struggles to infiltrate and attack tumors with more aneuploidy.

The study showed that targeted sequencing was feasible, identified many clinically relevant alterations, and directed effective targeted therapy in several cases.

The study also found that esophageal squamous cell carcinomas resemble head and neck cancer, while esophageal adenocarcinomas are similar to gastric cancers.

San Antonio River Walk

Using sequencing approaches, researchers are learning more about what drives breast cancer metastasis and resistance.

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The partially reinstated US travel ban leaves space for uncertainty for researchers, Nature News says.

Researchers find a number of traits differ by sex and could affect mouse model studies, according to Reuters.

Tweaking the skin microbiome could help address some skin conditions, the New York Times reports.

In PNAS this week: DNA methylation profiles of tumor tissue, gene dynamics in prokaryotes, and more.