Dana-Farber
Metastatic Melanoma Study Finds Immunotherapy Resistance Mutations in Immune-Linked Genes
Researchers identified acquired resistance mutations in metastatic melanoma, including alterations influencing innate immunity via changes to a protein transport complex.
Mass General Brigham Becomes Latest US Health System to Adopt Pretreatment DPYD Testing
The change in policy at the health system follows the death of a DPD deficient patient and comes during a period of intense competition among Boston hospitals.
Genomic Study Reveals Rearrangements Behind Female-Predominant Kidney Cancer
Researchers scoured dozens of tumor genome sequences to identify roles for active and inactive X chromosome sequences in Xp11 translocation renal cell carcinoma.
Genome Sequencing Adds 8 Percent to Diagnostic Yield for Rare Diseases Over Other Genetic Tests
Researchers found that genome sequencing uncovered several types of pathogenic variants that had eluded exome sequencing and other types of genetic tests.
Childhood Leukemia Study Leads to Ancient Variant Linked to Population-Specific Risk
Researchers tracked enhanced acute lymphoblastic leukemia rates in Hispanic/Latino ancestry children to a variant inherited from ancient Indigenous American ancestors.