CPTAC | GenomeWeb

CPTAC

Researcher Amanda Paulovich will develop multiple-reaction monitoring mass spectrometry assays and apply them to samples from cancer patients in the program.

The researchers found that using proteomic data in addition to mRNA data to predict gene function improves upon traditional transcriptomic approaches.

According to NCI, the MOUs will facilitate the coordination of research and sharing of data and tests for use by scientists and oncologists around the world.

Under the collaboration, University of Victoria researchers will add 2,000 new multiple reaction-monitoring mass spec assays to the CPTAC Assay Portal.

Announced this month, the project brings together CPTAC, the VA, and DoD, and has as its initial goal the proteogenomic analysis of 8,000 lung cancer patients.

The CPTAC study integrated proteomic and genomic data from 77 breast cancer tumors with the aim of identifying potential biomarkers and therapeutic targets.

Among other aims, the five-year effort hopes to use genomic and proteomic data to better understand patient drug response and the development of resistance.

The company plans to offer the immuno-MRM assays as kits covering sample prep and protein digestion as well as immuno-enrichment of specific peptides.

The organizations will use proteomics to characterize tumors and compare these proteomic characterizations to other forms of data including genomic profiles.

The sites will collect primary human tumors according to a protocol optimized for proteomics for the NCI's Clinical Proteomic Tumor Analysis Consortium.

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Harold Varmus, a former NIH director, says that proposed reductions to the agency's budget are worrisome.

The Genome 10K project is to sequence about 10,000 vertebrate genomes, including ones of endangered species, Digital Trends reports.

The new Coalition to Save NIH Funding aims to educate lawmakers and the public on the significance of biomedical research.

In PLOS this week: analysis of viral sequences from human blood samples, gut microbiomes of heart failure patients, and more.