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CRISPR researchers report that the gene-editing approach might have more off-target effects than thought and urge further refinement of the method.

The PREDICT/PDF-2180 virus is the latest coronavirus identified in a bat species, supporting a potential bat reservoir role in the evolution of such viruses.

Columbia University researchers uncover a gene variant associated with differential aging in the brain after the age of 65.

Mutation and expression patterns in longitudinal, multifocal, and solitary tumor samples suggest glioblastoma follows a multiverse model of evolution.

The partners aim to identify master regulators in the molecular networks of GIST patients that can serve as drug targets for existing treatments.

Heterozygous deletions at the chromosome 22q11.2 locus contribute to kidney problems in individuals with DiGeorge syndrome or congenital urogenital conditions.

The results suggest that targeted treatments used in rare epilepsies might also work in a portion of patients with common forms of the disease.

The software takes somatic mutation profiles from individual patients as input and uses them to prioritize relevant mutations and potential treatments.

Investigators will compare results using Biocept's platform in cerebrospinal fluid to current standard methods for diagnosing leptomeningeal metastases.

Under the PIPseq program, Columbia University researchers sequenced the exome, transcriptome, or a gene panel in tumors of 101 high-risk pediatric cancer patients.

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A South African university has told the Wellcome Sanger Institute to return DNA samples it has from indigenous African communities, The Times reports.

The University of California, Berkeley's Rasmus Nielsen and Xinzhu Wei have retracted their CCR5 gene paper due to a technical artifact.

 

University of Virginia researchers are exploring a genetic risk test to gauge type 1 diabetes risk, NPR reports.

In PNAS this week: researchers compare two high-grade neuroendocrine lung cancers, height among ancient Europeans, and more.